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PHARM 243 (Midterm 2) - Drugs > Endocrine 6 (Reproduction) > Flashcards

Endocrine 6 (Reproduction) Flashcards

1
Q

FSH (Female)

A

Estrogen Release

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2
Q

LH (Female)

A
  • Ovulation
  • Progesterone secretion from corpus luteum
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3
Q

Estradiol

A

Endogenous Estrogen
- Reproduction Action: ER Alpha & ER Beta
- Vascular Action: GPER / GPR30
–> Increase eNOS –> Increase NO –> Vasodilation

Most Potent

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4
Q

Estrone

A

Endogenous Estrogen
- Reproduction Action: ER Alpha & ER Beta
- Vascular Action: GPER / GPR30
–> Increase eNOS –> Increase NO –> Vasodilation

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5
Q

Estriol

A

Endogenous Estrogen
- Reproduction Action: ER Alpha & ER Beta
- Vascular Action: GPER / GPR30
–> Increase eNOS –> Increase NO –> Vasodilation

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6
Q

Ethinylestradiol

A

Synthetic Estrogen
- Reproduction Action: ER Alpha & ER Beta
- Vascular Action: GPER / GPR30
–> Increase eNOS –> Increase NO –> Vasodilation

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7
Q

Mestranol

A

Synthetic Estrogen
- Reproduction Action: ER Alpha & ER Beta
- Vascular Action: GPER / GPR30
–> Increase eNOS –> Increase NO –> Vasodilation

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8
Q

Progesterone

A

Controls the later secretory phase

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9
Q

Noresthisterone

A

2nd Generation Progestogen

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10
Q

Levonorgestrel

A

2nd Generation Progestogen
- Used in postcotical emergency contraception
- Used in nonbiodegradable capsule contraception

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11
Q

Ethynodiol

A

2nd Generation Progestogen

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12
Q

Desogestrel

A

3rd Generation Progestogen

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13
Q

Gestodene

A

3rd Generation Progestogen

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14
Q

Norethindrone

A

1st Generation Progestogen
- Used in Progestogen-Only Pills

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15
Q

Medroxyprogesterone

A

1st Generation Progestogen

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16
Q

Oxytocin

A

Affects uterine contraction
- Gq causing an increase of Calcium
- Calcium activates Calmodulin activates MLCK –> Uterine Contractions

17
Q

Ergometrine

A

May act on Alpha-Adrenoceptor and partly on 5-HT Receptors
- Stimulates Uterine Contraction

Stronger effect on relaxed uterus
Minimal effect on contracted uterus

18
Q

Domperidone

A

D2 Antagonist
- Treats Chemotherapy/Cytotoxic related Vomiting

19
Q

Metoclopramide

A

D2 Antagonist
- Treats Chemotherapy/Cytotoxic related Vomiting

20
Q

Profenamine

A

D2 Antagonist
- Treats Chemotherapy/Cytotoxic related Vomiting

21
Q

Mifepristone

A

Given first to allow for a lower dose of prostaglandin
- Followed by a Prostaglandin Analog

Competitive Progesterone Receptor Antagonist / Partial Agonist
- Sensitizes uterine muscles to prostaglandins
- Prostaglandin stimulates uterine contraction for abortion

22
Q

Misoprostol

A

Induces Medical Abortion
- Prostaglandin E1 Analog

Induces myometrial contraction leading to the expulsion of the fetus

23
Q

Gemeprost

A

Induces Medical Abortion
- Prostaglandin E1 Analog

Induces myometrial contraction leading to the expulsion of the fetus

24
Q

Dinoprostone

A

Induces Medical Abortion
- Prostaglandin E2 Analog

Induces myometrial contraction leading to the expulsion of the fetus

25
Q

Carboprost

A

Induces Medical Abortion
- Prostaglandin F2alpha Analog

Induces myometrial contraction leading to the expulsion of the fetus

26
Q

Atosiban

A

Competitive antagonist of oxytocin receptor
- Delays labour

Prevents increase of IP3
- No increase in intracellular calcium
- No increase in MLCK for uterine contraction

Suppresses oxytocin-induced release of prostaglandins

27
Q

Clomiphene

A

Competitive Estrogen Antagonist
- Inhibits negative feedback
- More Gonadotrophin
- More FSH

Adverse Effect:
- Reversible Ovarian Enlargement
- Manipulation of negative feedback often leads to twins

Treats Infertility

28
Q

Gonadorelin

A

Synthetic GnRH
- Given pulsatile to increase FSH

Used if Clomiphene does not work

Treats Infertility

29
Q

Follitropin

A

Recombinant FSH

Treats Infertility

30
Q

Lutropin

A

Recombinant LH

Treats Infertility

31
Q

Buserelin

A

GnRH Analogue
- Given pulsatile to increase FSH

Used if Clomiphene does not work

Treats Infertility

32
Q

Leuprorelin

A

GnRH Analogue
- Given pulsatile to increase FSH

Used if Clomiphene does not work

Treats Infertility

33
Q

Goserelin

A

GnRH Analogue
- Given pulsatile to increase FSH

Used if Clomiphene does not work

Treats Infertility

34
Q

Nafarelin

A

GnRH Analogue
- Given pulsatile to increase FSH

200x more potent than Gonadorelin (Synthetic GnRH)
Used if Clomiphene does not work

Treats Infertility

35
Q

Sildenafil

A

PDE V Inhibitor
- Prevent breakdown of cGMP
–> More activation of PKG
–> Vasodilation

Treats Erectile Dysfunction

36
Q

Tadalafil

A

PDE V Inhibitor
- Prevent breakdown of cGMP
–> More activation of PKG
–> Vasodilation

Treats Erectile Dysfunction

Longer Acting

37
Q

Vardenafil

A

PDE V Inhibitor
- Prevent breakdown of cGMP
–> More activation of PKG
–> Vasodilation

Treats Erectile Dysfunction

More specific for PDE V

PHARM 243 (Midterm 2) - Drugs (11 decks)

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