rheum systemic sclerosis

Question 1

what is systemic sclerosis

Answer 1

chronic disease characterized by abnormal connective tissue growth resulting in hardening and thickening of skin and often inner organs

Question 2

what are the two types of systemic sclerosis and which is more common

Answer 2

limited and diffuse

limited more common

Question 3

clinical presentation of limited ssc

Answer 3

CREST syndrome
calcinosis cutis

raynaud phoenomena(vasospasm of small vessels of fingers which often occurs due to cold conditions)

esophageal dysmotility which can lead to dysphagia and gerd which can further lead to barret esophagus

sclerodactyly which is fibrotic thickening of the skin of the fingers and hands. often initially edematous then fibrotic with waxy appeance and has red brown colour

telangeictasia

plus other cutaneous features such as ulcers

Question 4

clinical presentation of diffuse ssc

Answer 4

widespread disease and cutaneous features

extracutaneous features affecting esophagus causing esophaela dysmotility

lungs interstiial lung disease

heart fibrosis pericarditis myocarditis

renal fibrotic disease causing thickening of renal arteriolar wall leading to decreased blood flow

Question 5

which ntibody specific to to limited scc and diffuse scc

Answer 5

limited : anti centromere antibody

diffuse: anti scl 70 antibody and anti rna polymerase 3