Rheum- Systemic Sclerosis

Question 1

What is systemic sclerosis

Answer 1

Chronic disease caused by abnormal growth of connective tissue. Leads to thickening and hardening of the skin and often inner organs

Question 2

Describe CREST syndrome

Answer 2

C- calcinosis cutis which are small white calcium deposits on pressure points of extremities

R- raynaud phenomenon

E- esophageal hypomotility which can cause dysphagia Barrett esophagus gerd heart burn

S- sclerodactyly

T- telangiectasia

Question 3

Classify systemic sclerosis in two categories

Answer 3

Limited cutaneous and diffuse

Diffuse involves organs

Question 4

Diagnostic findings of systemic sclerosis

Answer 4

Presence of ANA in approx 90% of cases

Limited ssc: anticentromere antibodies(ACA)
Diffuse: anti scl -70
Anti rna polymerase 3

Increased gamma globulins on electrophoresis

Question 5

When is immunosuppressive therapy indicated in systemic sclerosis and what agent is used

Answer 5

If there is severe organ involvement

Methotrexate