Resp Sarcoidosis

Question 1

Ocular manifestations of sarcoidosis

Answer 1

Uveitis
Optic neuritis
Conjunctivitis

Question 2

Skin manifestations of sarcoidosis

Answer 2

Erythema nodosum
Lupus pernio: raised purple lesions on cheeks and nose
Granulomas develop in scar tissue

Question 3

Kidney manifestations of sarcoidosis

Answer 3

kidney stones due to hypercalcemia
Interstitial nephritis
Nephrocalcinosis

Question 4

Define lofgren syndrome

Answer 4

Erythema nodosum
Polyarthalgia
Bilateral hilar lymphadenopathy

Question 5

Gold standard investigation of choice for sarcoidosis along with other investigations necessary

Answer 5

Histology via bronchoscopy with ultrasound guided biopsy of mediastinal lymph nodes

Bloods: raised ace, hypercalcemia, raised interleukin 2receptor, raised crp,

Chest X-ray showing hilar lymphadenopathy

Check for organ involvement with Lfts,u and e, ophthal review etc

Question 6

Tx of choice

Answer 6

First line: no treatment

Oral steroids: dexa and orednisolone given for between 6&24 months with bisphosphonates to protect against osteoporosis with long term steroids

Second line: immunosuppressive such as azathioprine and methotrexate

Lung transplant