Derm Blistering Skin Conditions

Question 1

How can bullar be further subdivided and give example of each

Answer 1

Epidermal blister: separation of the layers of the epidermis.. pemphigus

Subepidermal: separation of the layers of the epidermis and dermis… bullous pemphigoid

Question 2

What is nikolsky sign

Answer 2

To separate epidermal from subepidermal blisters

Positive if you can grow the blister.. this is seen in epithelial blisters as they are more fragile

Question 3

What is pemphigus vulgaris

Answer 3

Infiltration by igg into epidermis attacking desmosomes linking keratinocytes

Question 4

Clinical presentation of pemphigus vulgaris

Answer 4

Painful flacid blisters of mucous membranes and skin
Nikolsky positive
Begin in mouth then spread elsewhere palms and soles spared

Question 5

Tx of pemphigus vulgaris

Answer 5

Methylprednisone

Question 6

Difference between pemphigus and erythema multiforme/sjs/ten

Answer 6

Spares soles of feet and palms

Sjs/ten treated with phenytoin, allopurinol, sulfas

Question 7

What is bullous pemphigoid

Answer 7

Igg against hemidesmosomes

Question 8

Clinical features of bullous pemphigoid

Answer 8

Tense fluid filled blisters
Nikolsky negative
Pruritic prodrome