Rheum

Question 1

Which cause of a red eye is associated with HLAB27 conditions?

Answer 1

Anterior uveitis

Question 2

Which plasma autoantibody has the highest specificity for rheumatoid arthritis?

Answer 2

Anti-CCP

Question 3

What autoantibodies are associated with Sjögren’s syndrome?

Answer 3

Anti-Ro
Anti-La
(Sjogrens patients have no tears RoLaring down their face)

Question 4

Which blood test is most specific for primary biliary cirrhosis?

Answer 4

Antimicrobial antibodies

Question 5

Which medications must allopurinol be used in caution with?

Answer 5

Azathioprine
Cyclophosphamide
Theophylline

(Increases risk of toxicity)

Question 6

What is primary biliary cholangitis?

Answer 6

Rule of M’s
(Middle aged women presenting with itching, IgM raised, antiMitochondrial antibiotics)

Autoimmune inflammation of intrahepatic bile ducts leading to cholestasis

Question 7

Allopurinol dose is titrated to achieve a uric acid level of what?

Answer 7

Less than 360

Use colchicine/ NSAID cover alongside allopurinol when initiating

Question 8

What drug is second line as a preventative agent for gout if allopurinol is not effective?

Answer 8

Febuxistat

Question 9

When would sulfasalazine be contraindicated?

Answer 9

If allergy to aspirin (SALAcylic acid, same derivative)

Or G6PD deficiency (can cause haemolysis)

(However sulfasalazine is safe to use in pregnancy and breast feeding)

Question 10

Which antibodies are often positive in SLE?

Answer 10

ANA (99% sensitive but not specific)
Anti-dsDNA
Anti- Smith

Question 11

Which antibodies are associated with drug induced lupus?

Answer 11

Antihistone antibody