Rheum

Question 1

HLA-B27

Answer 1

ankylosing spondylitits
reactive arthritis

Question 2

HLA-DQ2/8

Answer 2

coeliac disease

Question 3

HLA-A3

Answer 3

haemochromatosiss

Question 4

HLA-DR2

Answer 4

narcolepsy
goodpastures syndrome

Question 5

HLA-DR3

Answer 5

dermatitis herperitiformis
sjorgens syndrome
primary billiary cirrhosis

Question 6

HLA-DR4

Answer 6

T1DM
RA

Question 7

Anti-Jo1

Answer 7

Polymyositis and dermatomyositis

Question 8

Anti centromere

Answer 8

limited systemic sclerosis - aka CREST

Question 9

Anti-Scl-70

Answer 9

diffuse systemic sclerosis

Question 10

Anti-Ro

Answer 10

Sjorgens

Question 11

Anti-RNA polymerase III

Answer 11

nonspecific for systemic sclerosis
- more a marker of renal involvement

Question 12

antihistone

Answer 12

drug induced lupus

Question 13

ANA

Answer 13

SLE

Question 14

ANCA

Answer 14

various vasculitises

Question 15

AMA

Answer 15

PBC

Question 16

Ank spond MX

Answer 16

DMARDs found not to be useful –> form NSAIDs skip straight to biologics like etanercept / infliximab

Question 17

etanercept and infliximab are Egs of

Answer 17

tnf alpha blockers

Question 18

cANCA

Answer 18

granulomatosis w polyangiitis

Question 19

granulomatosis w polyangiitis Fx

Answer 19

ent stuff (sinusitis etc) + resp + kidney