MS Flashcards by Natasha Early | Brainscape

Q

acute relapse Mx

A

high dose steroids for 5 days to shorten course
(don’t affect degree of recovery just length of flare)

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Q

Indications for DMARDs

A

relapsing remitting disease + 2 relapses in past 2 years + ablte to walk 100m unaided
secondary progressive disease + 2 relapses in past 2 yrs + able to walk 10 (aided/unaided)

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Q

Natalizumab

A

monoclonal antibody –> antagonises integrin on surface of leukocytes
inhibit migration of leucocytes across endothelium into blood brain barrier
used first line (best evidence base)
given IV

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Q

Ocrelizumab

A

humanised antibody CD20 monoclonal antibody
often used first line too
given IV

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Q

fingolimod

A

S1P receptor modulator
prevents lymphocytes leaving lymph nodes
oral forms available

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Q

Mx of fatigue

A

amantadine
other options = mindfulness / CBT

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Q

Spaciticity Mx

A

baclofen and gabapentin first line
physio is important

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Q

Bladder dysfunction Mx

A

in form of urgency / incontinence / overflow
get USS to assess bladder emptying
if signic residual volume = intermittent self catheterization
if no signif residual volume = anticholinergics

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