Rh & ABO Flashcards
def of Rh Isoimmunization
Etiology of Rh Isoimmunization
Etiology of Rh Isoimmunization
- Any contact () Rh + ve fetal blood & maternal circulation
Etiology of Rh Isoimmunization
- Blood transfusion of Rh +ve blood to Rh -ve female at any age
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CP of Rh Isoimmunization
CP of Rh Isoimmunization
- Degrees
- Congenital hemolytic anemia: Mildest form
- Icterus gravis neonatorum: Commonest form
- Fetal hydrops: Rarest & most severe form
CP of Rh Isoimmunization
- Icterus gravis neonatorum
Dx of Rh Isoimmunziation
- US
Spectrophotometric analysis of AF in Rh Isoimmunization
- Indications
Fetal Blood Sampling in Rh Isoimmunization
Fetal Blood Sampling in Rh Isoimmunization
- Aim
Fetal Blood Sampling in Rh Isoimmunization
- Disadvantages
Complications of cordocentesis:
- More risky than serial amniocentesis.
- Feto-maternal Hge & consequently, massive ↑↑ in concentration of Abs.
- Thrombosis of umbilical vessels.
- Risk of fetal death (1.5%).
Neonatal Blood Sampling in Rh Isoimmunization
Prevention of Rh Isoimmunization
- Prevention of blood transfusion errors
- Anti-D Ig administration
Prevention of Rh Isoimmunization
- Prevention of blood transfusion errors
Never to give Rh +ve blood to Rh -ve females.
Prevention of Rh Isoimmunization
- Anti-D Ig administration
Anti-D Ig administration in Rh Isoimmunization
- Value
Anti-D Ig will destroy Rh +ve RBCs in maternal Circulation before sensitization.
Anti-D Ig administration in Rh Isoimmunization
- indications
Anti-D Ig administration in Rh Isoimmunization
- time of adminstartion
Within 72 hours after sensitizing event.
Anti-D Ig administration in Rh Isoimmunization
- Calculation of Dose
Plan managment in Rh Isoimmunization
- Algorithm
Intrauterine transfusion (IUT) in Rh Isoimmunization
- indications
- Fetal hydrops
- significant fetal anemia (Hb deficit > 2 gm/dl from mean for normal fetuses or Hct value < 30%).
Neonatal Care in Rh Isoimmunization
- exchange Transfusion
Criteria to Dx ABO Isoimmunization
Def of Non-Immune Fetal Hydrops
Etiology of Non-Immune Fetal Hydrops
Dx of Non-Immune Fetal Hydrops