Rh Flashcards
What type of cell destruction do Rh antibodies usually cause
Extravascular
Chromosome for Rh genes
Chromosome 1
Protein that is closely linked to Rh expression and function
RhAG
What is missing in the regulator pathway for Rh deletion
No functional RhAG protein so no Rhs
Rh null pathways
Regulator pathway (RhAg)
Amorph pathway (mutation in RHD/RHCE)
Which population can Rh null be found in
European background
What causes weak D
Genetic quantitative reduction in the amount of D antigen expressed. Detected by AHG usually
What does C in trans position cause
Weak expression of D. C in trans to D is another type of weak D expression
Del
Genetic quantitative reduction of D antigen to the point where you need adsorption/elution to detect it. Way less antigens than weak D
Mosaic or partial D
Qualitative change in the epitopes
Parts of the D antigen are missing
Can make anti-D
Weak vs partial D
Weak has less amount of D
Partial has missing parts of D
D variant that can make anti-D
Mosaic or partial D
How does f antigen work
Expressed when c and e are in the same haplotype
If anti-f provide c neg units
Which cells is G found in
Most D+ cells and all C+
Need adsorption/elution to distinguish between a D/C and G
What type of Ig class are Rh antibodies
IgG, do not bind complement well
(When they are first forming they are IgM)
