Kidd Flashcards
Kidd antigens developed in utero?
Yes, detectable as early as 6 weeks gestation
How do enzymes and DTT affect Kidd antigens
Enhanced by enzymes, resistant to DTT
What are Kidd antibodies known for
Falling below detectable levels in a short time, low titer
Null Kidd antigen
Jk3
Which population is the Jk null phenotype more commonly found in
Polynesian / Pacific Islanders
How do you identify a Jk null
Using 2M urea
Jk null cells are not lysed by urea
What are the ways you can inherit or have Jk null phenotype
Inherit mutated genes from both parents.
In(Jk) gene which inhibits/weakens Jk expression
Which Ig class are Kidd antibodies
IgG
Why do Kidd antibodies fall in levels so quickly
They are predominantly IgG3 class
IgG3 has half life of 7-8 days
Can Kidd antibodies bind complement
Yes, IgG Kidd antibodies cluster and activate complement
Positive frequency for Jka
W 77%
B 91%
Positive frequency for Jkb
W 73%
B 43%
