MNS

Question 1

Ss glycophorin

Answer 1

Glycophorin B

Question 2

Effect of enzymes and DTT on Ss

Answer 2

Enzymes destroy them, but can vary especially on little s
DTT doesn’t affect them

Question 3

What happens to Ss antigens with storage

Answer 3

They break down quickly so they might not be present on expired cells

Question 4

Positive frequency for S

Answer 4

W 55%
B 31%

Question 5

Positive frequency for little s

Answer 5

W 89%
B 93%

Question 6

Which race has the highest probability of being U-

Answer 6

African American

Question 7

What’s your phenotype if glycophorin B is missing

Answer 7

S- s- U-

Question 8

Effect of enzymes and DTT on U

Answer 8

Resistant to both

Question 9

Antibody Ig class for Ss

Answer 9

IgG

Question 10

Most to least frequent MNS haplotypes

Answer 10

Ns>Ms>MS>NS

Question 11

MN glycophorin

Answer 11

Glycophorin A

Question 12

Effect of enzymes and DTT on MN

Answer 12

Destroyed by ficin
Resistant to DTT

Question 13

Antibody Ig class

Answer 13

Mix of IgM and IgG but usually cold reactive
Do not bind complement
Can be naturally occurring

Question 14

Are MN antibodies significantly

Answer 14

Rarely ever significant
Do not bind complement

Question 15

Positive frequency M

Answer 15

W 78%
B 70%

Question 16

Positive frequency N

Answer 16

W 72%
B 74%

Question 17

Are anti-M and N naturally occurring?

Answer 17

Often they can be

Question 18

Who can autoanti-N be found in

Answer 18

Patient’s on dialysis when equipment was sterilized with formaldehyde