BB Intro

Question 1

First line of Defense Immunity

Answer 1

Innate or Natural Immunity

Question 2

Major players in Innate or Natural Immunity

Answer 2

Macrophages, Leukocytes, NK cells, complement alt pathway, cytokines

Question 3

Acquired or Adaptive immunity major players

Answer 3

Lymphocytes (T & B cells), macrophages, antibodies, complement classic pathway

Question 4

Cells responsable for production of antibodies

Answer 4

Activated B cells —> Plasma Cells

Question 5

First antibody class produced by plasma cells

Answer 5

IgM. T cell stimulation can turn it to IgG

Question 6

Most immunogenic blood group system

Answer 6

ABO (only major BGS)

Question 7

Most immunogenic antigen outside of ABO and immunogenicity %

Answer 7

D , 50%

Question 8

What percentage of proteins in the body are antibodies?

Answer 8

20%

Question 9

Name the 5 different Immunoglobulin classes

Answer 9

IgA, IgD, IgE, IgG, IgM

Question 10

Amino terminal regions in antibody structure

Answer 10

Fab

Question 11

Carboxyl region of antibody structure

Answer 11

Fc

Question 12

Fragment in antibody structure responsable for complement fixation

Answer 12

Fc region (carboxyl terminal/constant region)

Question 13

Where does complement bing on IgG molecule? (CH?)

Answer 13

CH2

Question 14

Where does macrophage bind on an IgG molecule? Ch?

Answer 14

CH3

Question 15

IgG classes that are most likely to be clinically significant and why

Answer 15

IgG 1 and 3. Because they bind complement the best.

Question 16

Which Ig type can cause immediate hypersensitivity?

Answer 16

IgE (allergic reactions)

Question 17

What is T cell deficiency called

Answer 17

DiGeorge syndrome

Question 18

What cell is missing in Burton’s Agammaglobulinemia?

Answer 18

Absence of mature B cells

Question 19

First response antibody timing and type

Answer 19

3-21 days. IgM (then it turns into IgG)

Question 20

Secondary response antibody timing and type

Answer 20

Also called anemnestic response. Faster IgG on second exposure. Curve goes up faster and a lot higher

Question 21

Portion of the complement cascade that binds to heavy chain

Answer 21

C1q binds to CH2 (complement attachment site)

Question 22

Complement pathway members that cause anaphylaxis

Answer 22

C4a , C3a , C5a ( the ones ending in a)

Question 23

Complement pathway members that form MAC

Answer 23

C5b C6 C7 C8 C9 form membrane attack complex MAC

Question 24

Probability of finding units formula

Answer 24

Number of units divided by the product of the negative frequencies (x100). Always round up

Question 25

Type of inheritance for Lu (ab)

Answer 25

Autosomal recessive

Question 26

Type of inheritance for Xga

Answer 26

Sex linked dominant

Question 27

Mitosis results and where it occurs

Answer 27

Two identical daughter cells. Occurs all over the body

Question 28

Meiosis results and where it occurs

Answer 28

Four half cells. Occurs in testes and ovaries

Question 29

Amorph

Answer 29

Allele does not code for protein

Question 30

Hemizygous

Answer 30

One allele is inherited and one is blank

Question 31

Cis allele location

Answer 31

Two alleles are on the same chromatid

Question 32

Trans allele location

Answer 32

Two alleles are on opposite chromatids