Kell

Question 1

Antigens formed in utero?

Answer 1

Yes, can be detected 7-10 weeks gestation

Question 2

What are Kell antigens rich in

Answer 2

Disulfide bonds

Question 3

Which chemicals denature kell antigens

Answer 3

DTT, AET, EGA, WARM, ZZAP

Question 4

Highs in Kell BGS

Answer 4

Little k, Kpb, Jsb

Question 5

K positive frequencies

Answer 5

W 9%
B 2%

Question 6

Little k positive frequencies

Answer 6

W 99.8%
B 100%

Question 7

In which population are Kpa and Jsa antigens found the most

Answer 7

Kpa+ in whites
Jsa+ in blacks

Question 8

What Ig type are Kell antibodies

Answer 8

IgG

Question 9

Kell antibodies clinically significant?

Answer 9

Yes, usually cause extravascular hemolysis

Question 10

What antibody can K null (K0) people form

Answer 10

K0 people can make anti-Ku

Question 11

Which gene is missing on McLeod phenotype

Answer 11

Kx

Question 12

What does lack of Kx antigen result in

Answer 12

McLeod Phenotype Kx- results in weakened expression of Kell BGS antigens

Question 13

Who can have the McLeod phenotype

Answer 13

Only males because it’s x-linked

Question 14

Which disease is often found on people with Kx McLeod phenotype

Answer 14

Chronic Granulomatous Disease (CGD)