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BB > Components > Flashcards

Components Flashcards

1
Q

Expiration date of and RBC when only anticoagulant is added. Exception to this?

A

21 days
Unless CPDA 1 is used then 35 days

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2
Q

MLs of anticoagulant per 100mL of blood

A

14mL per 100mL of WB
70 in one unit with 500mL of WB

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3
Q

Different Additive solutions

A

AS 1, 3, 5 and 7
1 and 3 are the most common

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4
Q

Additive solution with no mannitol

A

AS3

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5
Q

Required viability for a unit with AS added

A

75% viability 24 hrs post tx

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6
Q

Expiration date of a unit after AS

A

42 days

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7
Q

What kind of cells do you see when RBC membrane is lost

A

Spherocytes

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8
Q

How do RBCs generate energy

A

Anaerobically, from glucose

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9
Q

What decreases during storage for RBC storage lesion

A

Ph
Glucose consumption
ATP
Plasma Na+
2,3 DPG
Deformability

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10
Q

What increases during storage for RBC storage lesion

A

Lactic acid
Plasma K+
RBC Na*
Osmotic fragility
Adherence/interaction with endothelial cells

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11
Q

RBCs storage temp

A

1-6 C

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12
Q

Which ABO can be transfused for whole blood

A

Must be type specific

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13
Q

Exp date of RBC unit if system is open

A

24 hrs

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14
Q

QC for leukoreduction

A

Less than 5.0x10^6
But at least 85% of RBCs retained

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15
Q

Standard bump in HdB from one unit

A

1 g/dL increase in HgB or 3% Hct per unit

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16
Q

Deferral period for whole blood donation

A

8 weeks

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17
Q

Deferral period for aphaeresis double unit donation

A

16 weeks

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18
Q

QC for washing units

A

80% of RBCs to remain after washing

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19
Q

How long after expiration can a unit be rejuvenated

A

Up to 3 days after expiration

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20
Q

How long must a unit be transfused or frozen after rejuvenation

A

24 hrs

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21
Q

Frozen RBC temp and exp

A

10 years at -65C or colder (high glycerol, most common)
10 years at -120C or colder (low glyc)

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22
Q

How long is a thawed unit good for

A

If open system 24 hrs
If closed system 14 days

23
Q

QC for thawing RBCs

A

Must remain 80% of RBCs

24
Q

How long after collection must while blood derived platelets be harvested

A

Within 8 hours of collection

25
Q

How to collect platelets from WB spins

A

Soft spin then hard spin

26
Q

QC for pooled or WB derived platelets

A

Each dose must be 5.5x10^10 90% of the time.
6 doses are pooled to make one

27
Q

Exp for platelets

A

5 days

28
Q

Storage for platelets

A

20-24C with agitation

29
Q

pH requirement for platelets

A

Greater than or equal to 6.2

30
Q

Platelet exp date is system is opened

A

4 hours
Also 4 hours if pooled using open system

31
Q

QC for single donor platelets apheresis

A

3.0x10^11 90% of the time

32
Q

QC for irradiation

A

25-50 gray to the center
15 gray to the rest

33
Q

What does irradiation do

A

T lymphocytes are incapable of replicating
Prevents graft v host disease

34
Q

Exp date of irradiates unit

A

28 days or original if shorter

35
Q

Time for freezing fresh frozen plasma

A

Within 8 hours

36
Q

Time for freezing FP24

A

Within 24 hours

37
Q

Which type of plasma can cryo be manufactured from

A

FFP only

38
Q

FFP storage and exp

A

-18C or colder for 1 year
Or -65C for 7 years

39
Q

Which clotting factors does FFP contain

A

All factors
1mL of FFP contains 1 unit of each clotting factor

40
Q

Storage temp for plasma after thawing

A

1-6C

41
Q

How long is thawed FFP good for

A

24 hours
After that it can still be used for 5 days but it needs to be called thawed plasma (not FFP)

42
Q

Which factors are lower in plasma than FFP

A

Factor V and VIII

43
Q

When can liquid plasma be derived from WB

A

At any point during shelf life and up to 5 days after exp of unit

44
Q

Liquid plasma exp date

A

21 days

45
Q

From what and when is cryo manufactured

A

From FFP after it’s thawed at 1-6C

46
Q

How long after FFP is thawed must cryo be re frozen

A

1 hour

47
Q

What does cryo contain

A

Average of 250mg of fibrinogen, factor VIII, fibronectin, factor XIII and Von Willebrands factor

48
Q

Minimum cryo values

A

80 IU of factor VIII
150 fibrinogen

49
Q

Cryo storage temp and exp

A

-18C or colder for 1 year

50
Q

Cryo exp after thawing

A

6 hours closed system
4 hours open system
Starts when unit hits thawer

51
Q

Storage temp for cryo after thawing

A

20-24 C NO agitation

52
Q

How are granulocytes collected

A

Leukopheresis

53
Q

Granulocytes exp and storage

A

24 hrs store 20-24 no agitation
Best if given in 8 hrs

54
Q

Shipping temps for blood cryo FFP and platelets

A

RBCs 1-10 with wet ice
FFP and Cryo frozen with dry ice
Platelets 20-24

24 hrs max for delivery

BB (19 decks)

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