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BB > ABOH and Se > Flashcards

ABOH and Se Flashcards

1
Q

Most important blood group system

A

ABO

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2
Q

What is the inheritance pattern for A B and O antigens

A

A and B are co-dominant over O (recessive)

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3
Q

Which chromosome are ABO alleles on

A

Chromosome 19

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4
Q

Which substrate are ABO antigen built on

A

H

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5
Q

Precursor for H

A

Type 2 precursor chain

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6
Q

Name for the H gene

A

FUT1 gene (built on type 2 precursor chain)

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7
Q

Transferase that the H gene codes for

A

L-fucosyl transferace (L-fucose)

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8
Q

Chromosome location for ABO vs H

A

ABO- chromosome 9
H- chromosome 19

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9
Q

What type of gene is O

A

Amorph recessive

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10
Q

What transferase does A code for

A

N-Acetylgalactosaminyltransferase
(N-Acetylgalactosamine sugar, also called N-Acetyl-D-galactosamine)

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11
Q

What transferase does B code for

A

D Galactosyl transferase (D-galactose sugar)

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12
Q

If you inherit both A and B, which one will have more antigens? (AB type)

A

B is more competitive and there will be more B than A antigens

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13
Q

At what age do ABO antigens develop

A

5-6 weeks gestation

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14
Q

At what age do ABO antigens fully develop

A

2-4 years

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15
Q

ABO frequencies for Whites

A

O 45%
A 40%
B 11%
AB 4%

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16
Q

ABO frequencies for Blacks

A

O 50%
A 26%
B 20%
AB 4%

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17
Q

ABO frequencies for Hispanics

A

O 56%
A 31%
B 10%
AB 3%

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18
Q

ABO frequencies for Asians

A

O 40%
A 28%
B 25%
AB 7%

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19
Q

When do ABO antibodies start to develop

A

As early as 3 months after birth, usually 4-6 months
They are naturally occurring

20
Q

What antibody class are ABO antibodies

A

Predominantly IgM for group A and B people (IgM is the general answer)
Predominantly IgG for group O people

21
Q

What type would ABO antibodies detected at birth be?

A

IgG because IgM cannot cross placenta. Any antibodies seen are moms, so moms IgG ABO antibodies are the ones observed on baby

22
Q

Antibodies present in group O people

A

Anti-A, anti-B, and anti-A,B

23
Q

What type are reagent cells A1 and B

A

A1 are type A1 Rh negative
B are type B Rh negative

24
Q

Why is a saline control needed when typing AB people

A

To rule out possibility of panreactivity or autoagglutination

25
Q

Precursor substance for Se

A

Precursor substance 1 or type 1 chain

26
Q

Name for Se gene

A

FUT2

27
Q

Precursor substances

A

On RBC (H) type 2
On secretions (Se) type 1

28
Q

FUT genes

A

FUT1 H
FUT2 Se

29
Q

What transferase does Se produce

A

L-fucosyl transferase (same as H, which is why there is a H-like antigen in secretions)

30
Q

Percentage of population that are secretors

A

80%

31
Q

Bombay inherited alleles

A

hh/sese

32
Q

Parabombay inherited alleles

A

hh/Sese

33
Q

Difference between Bombay and Parabombay

A

Bombay don’t have H at all, parabombay have Se gene so they have H and can have A/B in their secretions, just not on rbc

34
Q

What would a Bombays ABO and screen look like

A

aBO would look normal like a type O. Screen would be reactive with all cells at all phases except for the autocontrol

35
Q

How to identify a bombay

A

Test with anti-H should be negative (ulex europaeus). Need RESt adsorptions to remove anti-H (cold)

36
Q

A1 vs A2

A

A1 people have A and A1 antigens
A2 people only have A

80% of A people are A1

37
Q

How to test for A1 vs A2

A

A1 will react with anti-A1 lectin
A2 will not

A2 people can make anti-A1

38
Q

Which A subgroups can make anti-A1

A

A2, A3, Ax are the main ones (not always and not naturally occurring for A2)
Ax and Ael usually make anti-A1 due to very weak A expression

39
Q

Which A subgroups would show MF reactions when typing

A

A3 and Aend

40
Q

Which A subgroup will react with anti-A1

A

A1 only

41
Q

Name for A1 lectin

A

Dolichos Bifloris

42
Q

Name for H lectin

A

Ulex europaeus

43
Q

Which B subgroup shows MF

A

B3

44
Q

Weakest subgroups of A and B

A

Ael and Bel
Type as O, need adsorption elution

45
Q

Greatest to leas amount of H on ABOs

A

O>A2>B>A2B>A1>A1B

46
Q

Name for B lectin

A

Bandeiraea simplicifolia

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