Revision notes: 8. Immunology Flashcards
Which type of hypersensitivity
Pernicious anaemia
Graves
Myasthenia gravis
Type 2 - antibody dependent
Complement activation via classical pathway
Which type of hypersensitivity
Rheumatoid
SLE
Glomerulonephritis
Type 3 - Immune complex deposition
Which type of hypersensitivity
Graft rejection
Type 4 - cell-mediated
Examples of attenuated vaccines
MMRBOYV
Mumps Measles Rubella BCG Polio Yellow fever Varicella
When does maternal IgG begin crossing placenta
12 weeks
peak at 32 weeks
What happens to TH-1 dependent conditions e.g. rheumatoid during pregnancy
Gets better
Progesterone suppresses TH-1
What happens to TH-2 dependent conditions during pregnancy
Get worse
E.g. SLE
When does foetus start making IgM
11 weeks
Measles mumps and rubella are all …. containing viruses
RNA
Intracellular bacteria
Chlamydia
Legionella
Mycobacterium TB
Coxiella
Plasma concentration of IgA
200mg/dL
Cancer marker for medullary thyroid cancer
carcinoembryonic antigen
Gardasil works against which HPV strains
6, 11, 16, 18
Inactivated bacterial vaccines
Tetanus
Diptheria
Inactivated viral vaccines
Polio
Influenza
Rabies
Hepatitis A
CD4+ T helper cells are divided into Th1 and Th2
Which secretes pro-inflammatory cytokines?
Th1
Which immunoglobulin is a dimer
IgA
HPV vaccine offers protection against which cancers
Cervical Vaginal Vulval Anal Oropharyngeal
Antigen presenting cells of the cervix
Langerhans
Monocytes make up ….. % of total leukocyte count
2-10%
Which vaccine type is absolutely contraindicated during pregnancy
Live-attenuated
CD3 - expressed by what
Co-receptor expressed by CD4+ and CD8+ T cells
Side effects of metronidazole
Urine discolouration
Peripheral neuropathy
