Revision notes: 5. Biochemistry

Question 1

Adrenergic receptor a1 - example functions

Answer 1

smooth muscle contraction (ureter, sphincter, uterus, vas deferens, erector pili
GIT smooth muscle relaxation
Arterial and venous vasoconstriction

Question 2

Adrenergic receptor b1 - example functions

Answer 2

chronotropic and inotropic effect on heart

Stimulates renin release

Question 3

Adrenergic receptor b2 - example function

Answer 3

smooth muscle relaxation (bronchi, uterus, detrusor)
Inhibit histamine release from mast cells
vasodilatory action
contracts anal sphincter

Question 4

Muscarinic receptor: example functions

Answer 4

increase endocrine and exocrine secretions
decrease heart rate
reduce cardiac contractility
smooth muscle contraction
vasodilation

Question 5

Name the three ketone bodies

Answer 5

B-hydroxybutyrate
Acetoacetic acid
acetone

Question 6

Haemoglobin: alpha globin - which chromosome?

Answer 6

16

Question 7

Haemoglobin: beta globin - which chromosome

Answer 7

11

Question 8

At what stage is foetal haemoglobin responsible for foetal oxygen transport

Answer 8

12 weeks gestation onwards

Question 9

What percentage of a newborn’s haemoglobin is HbF

Answer 9

50-95%

Question 10

Which enzyme catalyses conversion of testosterone to oestradiol

Answer 10

p450 aromatase inhibitor

Question 11

Most common enzyme deficiency in CAH

Answer 11

21-hydroxylase deficiency

Question 12

Alkalosis shifts oxygen dissociation curve to the

Answer 12

LEFT

Question 13

Acidosis shifts oxygen dissociation curve to the

Answer 13

RIGHT

Question 14

Ribosomes are contained in

Answer 14

ROUGH endoplasmic reticulum

Question 15

HbA1c target in pregnant women with DM

Answer 15

6.5%