Review for Block 1 Flashcards
A 68 year old present to the ER with suspected overdose of isoproterenol for the treatment of recent incidence of bradycardia. Which if the following symptoms is unlikely following overdose of an agonist selective for beta adrenergic receptor?
A) Bronchodilation B) increased release of renin C) Mydriasis D) Tachycardia E) Increrased gluconeogensis
Answer is C
Autonomic transmission can be inhibited by therapeutic agents following various mechanisms. Which of the following mechanisms describes best the action of hemocholinium on cholinergic transmission?
A) Blockage of NTS Storage B) Blockage of NTS synthesis C) Blockage NTS release D) Blockage of NTS uptake E) Blockage NTS degradation
B
Ach is the primary transmitter in autonomic system. A 34 female patient receives a prescription for a therapeutic agent known to intensify the transmission of Ach. Which of the following drugs has benn prescribed?
A) vesamicol B) reserpine C) Neostigmine D) atropine E) B. Toxin
Answer is C
A 37 year old patients has been admitted to the emergency room with suspected overdose of a potent selective beta-2 antagonist. Which of the following symptoms is likely to be experienced by the patient?
A) Accelerate heart rate B) Increased sweating C) Miosis D) cyclopegia E) Bronchoconstriction
Answer is E
A 57 years old patient has been admitted to the emergency room with suspected accidental poisoning of agricultural organophosphate insecticide. If untreated, the cause of death from such exposure would be?
A) Gastrointestinal bleeding B) Tachycardia C) Stroke D) hypotension E) Respiratory Failure
Answer: E
A 60 years old male patient has just received a prescription for a direct acting muscarinic cholinergic agonist. Based on you knowledge of the biological responses resulting from the stimulation of cholinergic transmission which of the following condition is being treated?
A) asthma B) Glaucoma C) Diarrhea D) Fever E) Anesthesia
Answer is B
A 60 years old male patient has just received a prescription for a direct acting muscarinic cholinergic agonist. All of the following drugs share the mechanism of the newly prescribed drug, Except:
A) tacrine B) Pilocarpine C) Muscarine D) Bethanechol E) Carbachol
Answer : B
A 2 years old child has been admitted to the emergency department. An overdose of an antimuscarinic agent is suspected. Antimuscarinic overdose is suspected. Possible of atropine overdose include?
A) GI cramps B) increased heart rate C) Increased gastric secretion D) Pupillary constriction E) Urinary frequency
Answer B
A 73 years old patient presents to your office with complains of nocturia, urinary frequency and urinary retention. He has family history of benign prostatic hyperplasia (BPH). He was diagnosed with BPH following PSA measurement, physical exam and urodynamic test. You prescribe a first-line drug for the management of BPH symptoms. Which of the following drugs has been prescribed?
A)Midodrine B)Sildenafil C)Furosemide D)Finasteride E)Terazosin
Answer is E
You are about to prescribe a diuretic to a 55 years old female patient for the treatment of hypertension. Her blood electrolyte test shows: Na 140 mEq/l (N 135 – 147 mEq/L); Ca 2.0 mEq/L (N 4.5 – 5.5 mEq/L; K 4.1 mEq/L (N 3.5 - 5.0 mEq/L). Which of the following diuretics would you prescribe?
A)Metozalone B)Furosemide C)Spironolactone D)Ethacrynic acid E)Mannitol
Answer is B
An investigational drug known to inhibit the release of norepinephrine is being evaluated for its safety profile in a phase 1 clinical trial. Which of the following drugs has the same mechanism of action?
A)Reserpine B)Metyrosine C)Vesamicol D)Guanethidine E)Botulinum toxin
Answer is D
A 53-year-old male with a history of smoking initially came to your hospital with chest pain occurring at rest. His ECG shows heart rhythms abnormalities. He was diagnosed with Prinzmetal’s angina. Prinzmetal’s angina is associated with significant arrhythmia, ventricular tachycardia, and ventricular fibrillation. Which of the following drugs is preferred for the treatment of variant angina?
A)Amlodipine B)Nadolol C)Isosorbide D)Lovastatin E)Nitroprusside
Answer is A
Ms. Smith has been on methyldopa for the past three weeks for the treatment of hypertension. Which of the following statements does NOT describe the therapeutic action of methyldopa?
A)Methyldopa is a prodrug
B)Its active metabolite is an agonist of alpha-1 receptor
C)Guanfacine and methyldopa act on the same adrenergic receptor
Methyldopa is a centrally acting D)drug
E)Safe during pregnancy
Answer is B
Mr. Peter is a diabetic patient who has been prescribed a beta blocker for the treatment of hypertension. Which of the following beta blocker would be appropriate in this patient?
A)Nadolol B)Atenolol C)Propranolol D)Betaxolol E)Nadolol
Answer is B
A 56 years old woman is brought into the emergency department. Mrs Jones is complaining about dizziness, fatigue and light-headedness. Upon examination her heart rate is 51beats/min (N: 60 – 100 beats/min). She explains that she has been on a heart medication for the past few days. The offending drug is identified as a beta blocker. Which of the following beta blockers is likely to be responsible for Mrs. Jones symptoms?
A)Acebutolol B)Pindolol C)Bucindolol D)Metoprolol E)None of the above
Answer is D
Selective COX2 inhibitors such as Celecoxib are known for their cardiovascular adverse effects. Which of the following prostaglandins mediates this adverse effect?
A)PGD2 B)PGE2 C)PGI2 D)PGF2alpha E)PGE1
Answer is C
Gout is characterized by high levels of uric acid. Uricosuric drugs enhance the excretion of uric acid in patients with gout. Which of the following drugs is a uricosuric agent?
A)Probenecid B)Colchicine C)Allopurinol D)Febuxostat E)Naproxen
Answer is A
Rheumatoid arthritis is an autoimmune disorder affecting the joints. Which of the following DMARDs inhibit the enzyme dihydrofolate reductase resulting in impaired production of nucleotides?
A)Hydroxychloroquine B)Leflunomide C)Auranofin D)Methotrexate E)D- Penicillamine
Answer is D
