ANS Flashcards
How does ANS work
it coordinates the regulation and integration of bodily functions. it works by the nervous system exerts it influence by the rapid transmission of electrical impulse over nerve fibers that terminate at effectors cells, which specifically respond to the release of NTS.
What are the parts of ANS
Adrenergic/ noradrenergic/ sympathetic - ACh is the primary neurochemical. adrenergic postganglionic is NE
Cholinergic/ parasympathetic/ Muscarinic - ACh
what are the 5 key feature of NTS functions
Synthesis Storage Release Termination of action of the tansmitter Receptor effects
How is choline transported into the presynaptic nerve
by a Na dependent choline transporter
What can inhibit the Na dependent choline transporter
hemicholinium
how is acetlychloine synthesized by
choline and acetyl-CoA by the enzyme choline acetyltransfase( ChAT). The ACh is then transported into the storage vesicle by a VAT.
What can inhibit the storage vesicle VAT
Vesamicol
What is stored in the VAT
Peptides, ATP and proteoglycan
What triggers the release of ACh
the trigger of the voltage sensitive calcium channels in the terminal membrane are open that allow for the influx of calcium and this leads to the release of ACh.
What can block ACh from being released and the calcium influx
Botulinium toxin
What is the process of tyrosine is the body
it is converted to dopamine and transported to a vesicle by the VMAT. it is then converted to NE by the enzyme dopamine Beta hydrolase.
What can block the transport of VMAT
Reserpine
What can block the release of NE
Quanethidline and bretylium
What is the rate limiting step for the conversion of tyrosine to dopamine
metyrosine
What happens when metyrosine
inhibits
there becomes a accumlation in patiens of tyramine and octopamine and is treated with MAO inhibitors.
