Retroviridae Part II Flashcards
Avian leukosis targets which cells? A. B-lymphocytes in bone marrow B. B-lymphocytes in the bursa of fabricius C. T-Lymphocytes mostly in the bursa of fabricius D. B and T lymphocytes in many lymphoid organs
B. Lymphocytes, with B-lymphocyte markers in the bursa of fabricius
Exogenous replication of competent avian leukosis viruses results in the following conditions: A. Lymphoid Leukemia (Big liver Dz) B. Osteopetrosis C. Renal Tumors D. B and C only
D. Competent results in: Lymphoid leukosis (visceral lymphomatosis, big liver dz) Osteopetrosis (Thick Leg), and renal tumors
Exogenous replication of defective avian leukosis viruses results in the following conditions: A. Erythroblastosis B. Leukemia C. visceral lymphomatosis D. Anemia E. A, B, and D.
E. defective results in: Erythroblastosis, Myeloblastosis, Myelocytomatosis —–> Anemia, Leukemia
Match correctly for Avian Leukosis:
- Vertical transmission via egg/first few days of life 2. Vertical transmission via proviral integration into host germ cell line 3. Horizontal transmission after 5-6 days old ____________________________________________
A. Latent state; no viremia or leukemia B. Immunological tolerance and life-long viremia; leukemia probable. C. Infection and transient viremia, with development of neutralizing antibodies
- B 2. A 3. C
T or F: Subgroup E of Avian Leukosis is genetically inherited and is oncogenic.
F: It is non-oncogenic
T or F: Avian Leukosis is an alpharetrovirus which has 6 subgroups.
F; 10 subgroups
The following are TRUE of FIV except: A. It is a lentivirus B. It has 5 subtypes based on differences in env gene C. Subtypes A and B are prominent in N. America D. The main mode of transmission is cat bites. E. All of the above are true.
E.
T or F: the hallmark of FIV is the disruption of immune function, which is caused by a progressive loss of CD4+ Helper T-cells.
T.
The following are mechanisms by which FIV results in CD4+ cell loss: A. Cytotoxic T-cell-mediated cytolysis of infected CD4+ B. Apoptosis of infected cells C. Cytopathic effect of FIV viruses D. Bone marrow or thymic infection will cause decreased production of CD4+ cells. E. All of the above.
E.
T or F: In the acute phase of FIV, cats will exhibit transient signs such as diarrhea, malaise, and lymphadenopathy, and fever, and neutralizing antibodies can be detected in the blood.
F. The Abs detected are ineffective at eliminating or neutralizing virus
The latent phase of FIV is characterized by the following: A. Transient diarrhea and fever B. Persistent lymphadenopathy C. No detectable clinical signs. D. A and B
B. Ghosh stressed persistent lymphadenopathy as being the only thing clinically seen; there can be no other signs for years.
The terminal phase of FIV is characterized by: A. Acquired Immunodeficiency Syndrome (Feline AIDS) B. Chronic recurrent bacterial and fungal infections C. Gingivitis and stomatitis D. Respiratory disease E. Diarrhea and wasting F. All of the above.
F.
The SNAP test for FIV detects what? A. pE1 envelope protein antibody B. p24 core protein antibody C. p17 core protein antigen D. p24 core protein antigen
B.
Which of the following is FALSE regarding Equine Infectious Anemia? A. It is a lentivirus, also called Swamp Fever B. Transmitted mechanically by stable flies, tabanids, mosquitos and Culucoides spp. C. Results in an intermittent viremia that lasts 30 days. D. Results in persistent Ag-Ab complex Hypersensitivity reaction. E. All of the above are true.
C. LIFELONG VIREMIA!!!
Common sequelae of Equine Infectious Anemia are: A. Spinal leptomeningitis and encephalomyelitis B. Glomerulonephritis C. Hepatic and other parenchymatous organ inflammation D. Vasculitis E. Anemia F. All of the above.
F.
