Reticular Formation and Limbic System Anatomy Flashcards
where is the reticular formation located?
central core of the brainstem including the midbrain, pons and medulla
what are the three regions of the reticular formation in the brainstem?
raphe nuclei
medial zone
lateral zone
what are the five NTs in the reticular formation?
serotonin acetycholine dopamine NE Epinephrine
where are the cell bodies of cholinergic neurons in the reticular formation?
pedunculopontine nucleus
nucleus basalis of meynert
what is the projection of the pedunculopontine nucleus?
forebrain, basal ganglia, cerebellum, brainstem, thalamus
what is the fxn of the pedunculopine and nucleus basalis of meynert cholinergic neurons?
movement, learning, memory, arousal attention and sleep
where are the cell bodies of dopaminergic neurons in the reticular formation?
substantia nigra and ventral tegmental area
what are the projections of dopaminergic neurons from the substantia nigra?
nigrostriatal pathway
what is the fxn of dopaminergic neurons in the nigrostriatal pathway?
movement/movement disorder
what are the projections of the dopaminergic neurons in the ventral tegmental area?
mesolimbic pathway
mesocortical pathway
what is the fxn of dopaminergic neurons projecting into the mesolimbic pathway?
reward/pleasure/motivation…goes to nucleus accumbens
what is the fxn of dopaminergic neurons projecting to the mesocortical pathway?
cognition, planning learning
where are the cell bodies of serotonergic neurons in the reticular formation?
raphe nucleus
where do serotonergic neurons project from the raphe nucleus?
forebrain, brainstem, cerebellum, and SC
what is the fxn of serotonergic neurons in the reticular formation?
mood, appetite, sleep wake cycle, pain modulation
where are the cell bodies of noradrenergic neurons in the reticular formation?
locus coeruleus
where is the locus ceruleus located?
midbrain
where do noradrenergic neurons from the locus ceruleus project?
forebrain, brainstem, cerebellm and spinal cord
what is the fxn of noradrenergic neurons in the reticular formation?
attention/arousal
the reticular activating system goes where? what does it stimulate?
cortex…stimulates sleep/wake transitions and arousal
what is the role of the basal ganglia?
modulation of voluntary movement
what is the role of the limbic system?
mood/emotion
motivated behaviors
pain unpleasantness
name the two diencephalon components of the limbic system
anterior nuclei of the thalamus and mammilary bodies of the hypothalamus
name the six parts of the cerebral hemi that are involved in the limbic system
cingulate gyrus parahippocampal gyrus dentate gyrus fornix amygdala hippocampus
what is the fxn of the cingulate gyrus?
enthusiasm/passion
pain unpleasantness/avoidance
what is the fxn of the parahippocampal gyrus?
memory of faces/places
what is the fxn of the amygdala?
fear/anxiety/aggression
what is the fxn of the hippocampus?
learning/memory
what is unique about the hippocampus?
very epileptogenic…makes seizures
the mamillary bodies of the hypothalamus receive memory input from where?
hippocampus
what is the fxn of the mamillary bodies in the hypothalamus?
memory
the anterior nuclear group of the thalamus receives input from where?
mammillary bodies of the hypothalamus
what is the fxn of the anterior nuclear group of the thalamus?
learning and memory
what are the five Fs of the limbic system?
feeding, fighting fleeing, feeling and F&&&ing
what are the three steps in the reward pathway?
ventral tegmental area to the nucleus accumbens to the prefrontal cortex
