Reticular Formation and Limbic System Anatomy Flashcards

1
Q

where is the reticular formation located?

A

central core of the brainstem including the midbrain, pons and medulla

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2
Q

what are the three regions of the reticular formation in the brainstem?

A

raphe nuclei
medial zone
lateral zone

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3
Q

what are the five NTs in the reticular formation?

A
serotonin
acetycholine
dopamine
NE
Epinephrine
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4
Q

where are the cell bodies of cholinergic neurons in the reticular formation?

A

pedunculopontine nucleus

nucleus basalis of meynert

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5
Q

what is the projection of the pedunculopontine nucleus?

A

forebrain, basal ganglia, cerebellum, brainstem, thalamus

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6
Q

what is the fxn of the pedunculopine and nucleus basalis of meynert cholinergic neurons?

A

movement, learning, memory, arousal attention and sleep

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7
Q

where are the cell bodies of dopaminergic neurons in the reticular formation?

A

substantia nigra and ventral tegmental area

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8
Q

what are the projections of dopaminergic neurons from the substantia nigra?

A

nigrostriatal pathway

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9
Q

what is the fxn of dopaminergic neurons in the nigrostriatal pathway?

A

movement/movement disorder

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10
Q

what are the projections of the dopaminergic neurons in the ventral tegmental area?

A

mesolimbic pathway

mesocortical pathway

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11
Q

what is the fxn of dopaminergic neurons projecting into the mesolimbic pathway?

A

reward/pleasure/motivation…goes to nucleus accumbens

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12
Q

what is the fxn of dopaminergic neurons projecting to the mesocortical pathway?

A

cognition, planning learning

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13
Q

where are the cell bodies of serotonergic neurons in the reticular formation?

A

raphe nucleus

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14
Q

where do serotonergic neurons project from the raphe nucleus?

A

forebrain, brainstem, cerebellum, and SC

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15
Q

what is the fxn of serotonergic neurons in the reticular formation?

A

mood, appetite, sleep wake cycle, pain modulation

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16
Q

where are the cell bodies of noradrenergic neurons in the reticular formation?

A

locus coeruleus

17
Q

where is the locus ceruleus located?

18
Q

where do noradrenergic neurons from the locus ceruleus project?

A

forebrain, brainstem, cerebellm and spinal cord

19
Q

what is the fxn of noradrenergic neurons in the reticular formation?

A

attention/arousal

20
Q

the reticular activating system goes where? what does it stimulate?

A

cortex…stimulates sleep/wake transitions and arousal

21
Q

what is the role of the basal ganglia?

A

modulation of voluntary movement

22
Q

what is the role of the limbic system?

A

mood/emotion
motivated behaviors
pain unpleasantness

23
Q

name the two diencephalon components of the limbic system

A

anterior nuclei of the thalamus and mammilary bodies of the hypothalamus

24
Q

name the six parts of the cerebral hemi that are involved in the limbic system

A
cingulate gyrus
parahippocampal gyrus
dentate gyrus
fornix
amygdala
hippocampus
25
what is the fxn of the cingulate gyrus?
enthusiasm/passion | pain unpleasantness/avoidance
26
what is the fxn of the parahippocampal gyrus?
memory of faces/places
27
what is the fxn of the amygdala?
fear/anxiety/aggression
28
what is the fxn of the hippocampus?
learning/memory
29
what is unique about the hippocampus?
very epileptogenic...makes seizures
30
the mamillary bodies of the hypothalamus receive memory input from where?
hippocampus
31
what is the fxn of the mamillary bodies in the hypothalamus?
memory
32
the anterior nuclear group of the thalamus receives input from where?
mammillary bodies of the hypothalamus
33
what is the fxn of the anterior nuclear group of the thalamus?
learning and memory
34
what are the five Fs of the limbic system?
feeding, fighting fleeing, feeling and F&&&ing
35
what are the three steps in the reward pathway?
ventral tegmental area to the nucleus accumbens to the prefrontal cortex