Reticular Formation and Limbic System Anatomy Flashcards

1
Q

where is the reticular formation located?

A

central core of the brainstem including the midbrain, pons and medulla

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2
Q

what are the three regions of the reticular formation in the brainstem?

A

raphe nuclei
medial zone
lateral zone

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3
Q

what are the five NTs in the reticular formation?

A
serotonin
acetycholine
dopamine
NE
Epinephrine
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4
Q

where are the cell bodies of cholinergic neurons in the reticular formation?

A

pedunculopontine nucleus

nucleus basalis of meynert

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5
Q

what is the projection of the pedunculopontine nucleus?

A

forebrain, basal ganglia, cerebellum, brainstem, thalamus

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6
Q

what is the fxn of the pedunculopine and nucleus basalis of meynert cholinergic neurons?

A

movement, learning, memory, arousal attention and sleep

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7
Q

where are the cell bodies of dopaminergic neurons in the reticular formation?

A

substantia nigra and ventral tegmental area

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8
Q

what are the projections of dopaminergic neurons from the substantia nigra?

A

nigrostriatal pathway

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9
Q

what is the fxn of dopaminergic neurons in the nigrostriatal pathway?

A

movement/movement disorder

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10
Q

what are the projections of the dopaminergic neurons in the ventral tegmental area?

A

mesolimbic pathway

mesocortical pathway

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11
Q

what is the fxn of dopaminergic neurons projecting into the mesolimbic pathway?

A

reward/pleasure/motivation…goes to nucleus accumbens

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12
Q

what is the fxn of dopaminergic neurons projecting to the mesocortical pathway?

A

cognition, planning learning

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13
Q

where are the cell bodies of serotonergic neurons in the reticular formation?

A

raphe nucleus

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14
Q

where do serotonergic neurons project from the raphe nucleus?

A

forebrain, brainstem, cerebellum, and SC

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15
Q

what is the fxn of serotonergic neurons in the reticular formation?

A

mood, appetite, sleep wake cycle, pain modulation

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16
Q

where are the cell bodies of noradrenergic neurons in the reticular formation?

A

locus coeruleus

17
Q

where is the locus ceruleus located?

A

midbrain

18
Q

where do noradrenergic neurons from the locus ceruleus project?

A

forebrain, brainstem, cerebellm and spinal cord

19
Q

what is the fxn of noradrenergic neurons in the reticular formation?

A

attention/arousal

20
Q

the reticular activating system goes where? what does it stimulate?

A

cortex…stimulates sleep/wake transitions and arousal

21
Q

what is the role of the basal ganglia?

A

modulation of voluntary movement

22
Q

what is the role of the limbic system?

A

mood/emotion
motivated behaviors
pain unpleasantness

23
Q

name the two diencephalon components of the limbic system

A

anterior nuclei of the thalamus and mammilary bodies of the hypothalamus

24
Q

name the six parts of the cerebral hemi that are involved in the limbic system

A
cingulate gyrus
parahippocampal gyrus
dentate gyrus
fornix
amygdala
hippocampus
25
Q

what is the fxn of the cingulate gyrus?

A

enthusiasm/passion

pain unpleasantness/avoidance

26
Q

what is the fxn of the parahippocampal gyrus?

A

memory of faces/places

27
Q

what is the fxn of the amygdala?

A

fear/anxiety/aggression

28
Q

what is the fxn of the hippocampus?

A

learning/memory

29
Q

what is unique about the hippocampus?

A

very epileptogenic…makes seizures

30
Q

the mamillary bodies of the hypothalamus receive memory input from where?

A

hippocampus

31
Q

what is the fxn of the mamillary bodies in the hypothalamus?

A

memory

32
Q

the anterior nuclear group of the thalamus receives input from where?

A

mammillary bodies of the hypothalamus

33
Q

what is the fxn of the anterior nuclear group of the thalamus?

A

learning and memory

34
Q

what are the five Fs of the limbic system?

A

feeding, fighting fleeing, feeling and F&&&ing

35
Q

what are the three steps in the reward pathway?

A

ventral tegmental area to the nucleus accumbens to the prefrontal cortex