Restrictive Thoracic disease Flashcards
What causes outwith the lungs cause restriction?
- Skeletal (eg spinal curvature/ traumatic multiple rib fracture)
- Muscle weakness in Intercostal muscles/diaphragm (myopathy/neuropathy/meylopathy)
- Abdominal obesity/ ascites/ pregnancy
What does type II respiratory failure cause?
hypo-ventilation
low PaO2
reduced lung volumes
Aa barrier means?
Alveolar-arterial barrier
Which gas can be easily passed through the Aa barrier?
CO2
DPLD is an example of disease in which lung structure?
Alveoli
DPLD does what to partial pressures in the alveoli?
decreased PaO2
normal CO2
What is the most common cause of fluid in the alveolar air spaces?
Cardiac pulmonary oedema
raised pulmonary venous pressure
Non cardiac pulmonary oedema is due to?
leaky pulmonary capillaries
sepsis/trauma
Consolidation is?
when alveolar air space becomes filled with infection
What can cause infective consolidation pneumonia?
viral
bacterial
fungal
parasites
Pulmonary emboli and vasculitis can cause?
Pulmonary Infarction
other causes of BOOP? (broncheolitis oblierans organising pneumonia)
rheumatoid disease
drugs
cryptogenic
Extrinsic allergic alveolitis is which type of reaction?
IgG mediated type 3 hypersensitivity pneumonitis reaction
farmers lung and avian flu are an example of?
Extrinsic- allergic- alveolitis
what are the two branches of granulomatous alveolitis?
- extrinsic allergic alveolitis
2. sarcoidosis
What is sarcoidosis?
multi-system disease
rash on legs
inflammation in eyes/heart/nerves
Granulomatous alveolitis in lungs
Drugs that induce alveolitis?
amiodarone
bleomycin/methotrexate
what is pulmonary fibrosis?
An alveolitis that lays down collagen in the alveolar wall (simultanously to neutrophilic response)
What conditions are pulmonary fibrosis associated with?
idiopathic pulmonary fibrosis
rheumatoid
Pneumoconiosis is?
dust disease
Fibrogenic pneumoconiosis examples?
Asbestosis
Silicosis
Non-fibrogenic pneumoconiosis examles?
siderosis
stanosis
baritosis
Cancers associated with carcinomatosis?
adenocarcinomas- bronchus breast prostate colon stomach
where are eosinophils in DPLD?
lung tissue