Respiratory Tract Infections Flashcards
what is the main problem with respiratory tract infections?
secondary infections
how is the nasopharynx adapted for respiratory tract infections?
very adapted with innate and adaptive immunity to prevent infection
Saliva - absorb virus particles and bacteria, as well as having antimicrobial peptides present
Alveolar macrophages
Virus are very common and change rapidly so don’t develop immunity - hence why colds/coughs common
issue with viruses and host immunity
Virus are very common and change rapidly so don’t develop immunity - hence why colds/coughs common
3 most common upper respiratory tract infections
sinusitis (rhinosinusitis)
tonsilitis
pharygitis
sinusitis (rhinosinusitis)
inflammation of sinuses
nice environment for bacteria to grow
pharyngitis
red swollen throat
best way to treat upper respiratory tract infections
gargle with salt water or chlorohexidine
generally don’t need antibiotic
what type of infection are most URT infections?
viral
key bacteria that can infect URT
streptococcis pyogens
bordatalla pertusis
what % aetiology is viral for Tonsillitis/Pharyngitis?
70
what viruses can cause Tonsillitis/Pharyngitis?
rhinovirus (common cold)
adenovirus
parainflluenza
others
what causes glandular fever?
Epstein Barr Virus
what does Epstein Barr glandular fever effect?
Effects lymph nodes, out of work for up to 6 months potentially
how does a viral particle progress in the body
- Virus attached to epithelia
- Gets inside the cells
- Divides rapidly
- Causes cell to self-destruct
- Virus shedding
- Macrophages may come along to tidy things up
- Disrupt viral membranes
If unchecked bacteria can take over
Fundamentally should recover in short period of time
what does the viral particle induce in the host?
physiological response
chemical mediators of inflammation –> vascular dilation –> nasal obstruction
increased vascular permeability –> serum transudation —> rhinorrhea
sensitisation and irritation of airways receptors –> cholinergic stimulation –> bronchoconstriction —> cough
what causes 25% of sore throats?
S.pyogens (group A)
resides in nasopharynx
what % of children are asymptotic carriers of S.pyogens (group A)?
15-20%
what is a pathogenic virus?
Viral strain adapted to causing disease e.g. S.pyogens (group A)
what is a cariogenic organism
S.mutans
whats dies Group A Strep Pyogens produces as Virulence factors?
- pyrogenic exotoxins
- streptolysins
- hyaluronidase
- M protein
what do exotoxins made by Strep Pyogens do?
Exotoxins break up cell membranes, blood cells and collagen fibres
what do M proteins made by Strep Pyogens do?
Surrounds the organism
Prevents desiccation
potential M protein secondary effects
M protein looks like self-protein
- antibody response to M protein
Attack cardiac tissue
- rheumatic fever (caused by antigens), myocarditis
possible complications of streptococcal sore throat
- peri-tonsillar abscess
- ottis media or sinusitis
- scarlet fever (less common)
- rheumatic fever
- rheumatic heart disease
- acute glomerulonephritis
rheumatic fever
indirect complication of streptococcal sore throat
antibodies to antigens in streptococcal cell wall cross-react with the sarcolemma of human heart
rheumatic heart disease
repeated attacks of streptococcus pyogenes infection can result in damage to heart valves
future attacks prevented by penicillin prophylaxis in childhood
asthma
upper airways affected fairly common - Airways decrease - Mucous build ups - plugs - Cough to try and remove the mucous - Smoke and allergies can stimulate asthma
All culminate to cause bronchitis
bronchitis
inflammation of the tracheobronchial tree
acute bronchitis occurs when
usually during winter months
most often viral infection
chronic bronchitis is
Productive cough on most days during at least 3 months in each of 2 successive years.
- Affects 10-25% of population.
Predisposing = Smoking, infection, air pollution & allergies
Viral & bacterial agents
chronic bronchitis affects
10-25% of population
causes of chronic bronchitis
Predisposing = Smoking, infection, air pollution & allergies
Viral & bacterial agents
virus Vs bacteria upper respiratory infection causes
virus 90%
bacteria 10%
common viral infections of upper respiratory tract
- rhinovirus
- Influenza
- adenovirus
common bacteria infections of upper respiratory tract
- Bordatella pertussis
- Mycoplasma pneumoniae
- Chlamydia pneumoniae
- Haemophilus influenzae
Bordatella pertussis of upper respiratory tract
hooping cough, can be fatal
- Cough till sick
- Produces an exotoxin - stimulate the upper bronchi
- Lots of energy needed, may need incubated and hospitalised