Renal Medicine Flashcards
3 tubes leaving kidney
artery
vein
ureter
what does the glomerulus filtrate
plasma
what does the glomerulus connect to
collecting duct
what controls the pressure of glomerulus filtration
afferent and efferent blood vessels
what causes changes changes in afferent and efferent blood vessels
muscular traps squeeze vessels open and shut so ml/hour constant
what is the effect of the renal artery having a high BP
the renal artery will shut off to reduce the pressure going into the glomerulus
maintain same pressure difference despite high BP to maintain filtration
act of renin
reduce BP
low BP means short of circulating volume so retain more fluid
how does the glomerulus filtrate
it is a membrane with holes in it
what cannot filter through the glomerulus
cells and proteins
what does cells and proteins in urine indicate
disease
particularly of the glomerulus
what is the role of the collecting duct system
secretion and reabsorption of electrolytes
- modify the electrolyte
what is the role of the collecting tubule
fluid reabsorption
- modify volume
diabetes insipidus
pee a lot of normal type urine
polyuria
pee too much
dysuria
pain when passing urine
haematuria
blood in urine
- microscopic
- stained red
proteinuria
protein in urine
- should not be if glomerulus is working well
- holes too small for proteins
- more leaky if inflammed
uraemia
waste products that should be extracted by kidney are not so accumulate in blood
3 measuring renal function
serum UREA
serum creatinine
24 hr urine collection
urea level in urine
waste product from body
constant level
increase in urea also increase water excretion
- dehydration
- poor renal function
not a good marker to use
serum creatinine in urine
good general guide to renal function
should be generally low
if kidney not working well then will rise
24hr urine collection
Creatinine clearance – best measure
Faff procedure to carry out
EGFR is mainly used in clinic
4 consequences of renal failure
loss of renal excretory function
loss of water and electrolyte balance
- cannot modify or concentrate amount in system
loss of acid base balance
- loss H ions or base
- compensate by ventilation partially
- CO2 removal from body is same as removing H ions from Kidney
loss of renal endocrine function
3 endocrine functions of the kidney
Erythropoietin
- Become anaemic (lack of RBC)
calcium metabolism
- less production of vitamin D dependent factors
- not normal Ca metabolism
renin secretion
2 types of renal failure
acute
chronic
acute renal failure
rapid loss of renal function
usually over hours or days
- infection
- trauma e.g. accident
muscle injury causes muscle proteins to be broken down and circulate in blood stream to kidneys
swamp glomerulus as too many proteins
block holes so not able to filter plasma effectively
- medicines – can be toxic
sudden and quick
pt notice as become unwell
need tx till kidney can recover
chronic renal failure
gradual loss of renal function
usually over many years (10-20years)
3 possible causes of acute renal failure
infection
trauma
medicine