Respiratory Pharmacology

Question 1

Theophylline MOA? AE?

Answer 1

MOA: inhibits phosphodiesterase=>increased cAMP and bronchodilation

AE: inhibits adenosine, ventricular arrhythmia/tachycardia

Question 2

Ipratropium MOA? DOC for? Long Form?

Answer 2

MOA: competitively blocks muscarinic receptors=> preventing bronchoconstriction
DOC: Bronchospasm caused by B-Blockers
Long Form: Tiotropium

Question 3

Cromolyn MOA? Use? AE?

Answer 3

MOA: prevents degranulation of mast cellsUse: seasonal allergies
AE: throat irritation

Question 4

Fluticasone/budesonide MOA? 1st line for? AE?

Answer 4

MOA: 1. Inhibit all cytokine 2. Inhibit NF-kB (the transcription factor that induces TNF-alpha)
DOC: Chronic Asthma
AE: oral candidiasis

Question 5

Dextromethorphan MOA? Antidote?

Answer 5

MOA: blocks NMDA glutamate receptors
Antidote: Naloxone

Question 6

Zileuton MOA? AE?

Answer 6

MOA: 5-lipoxygenase pathway inhibitor. Blocks conversion of arachidonic acid to leukotrienes.

AE: Hepatotoxic

Question 7

B2 long agents?

Answer 7

Salmeterol, formoterol

Question 8

Omalizumab MOA?

Answer 8

MOA: Monoclonal anti-IgE antibody that stops IgE from binding to FcεRI

Question 9

What are the 2nd generation H1 blockers?

Answer 9

Come And Dine

Loratadine, fexofenadine, desloratadine, cetirizine

Question 10

Pseudoephedrine, phenylephrine MOA?

Answer 10

MOA: α-adrenergic agonists

AE: HTN

Question 11

Bosentan MOA?

Answer 11

MOA: Competitively antagonize endothelin-1 receptors=> decreased ??pulmonary vascular resistance.

Use: Pul HTN
AE: Hepatotoxicity

Question 12

sildenafil MOA?

Answer 12

MOA: Inhibit cGMP PDE5 and prolong vasodilatory effect of nitric oxide