Lung Cancer

Question 1

Pancoast Tumor (superior sulcus tumor) affects? How does it cause Horner Syndrome and Hoarseness?

Answer 1

Apex of the Lung

Cervical Sympathetic Chain

Question 2

Facial Plethora, blanching after fingertip pressure and JVD=?

Answer 2

SVC syndrome

Question 3

SVC syndrome is due to?

Answer 3

Pancoast tumor or indwelling catheters

Question 4

Why is SVC syndrome a problem?

Answer 4

Can Increase ICP=>Increased Risk of aneurysm/rupture of intracranial arteries

Question 5

SCLC (oat cell) describe in one phrase?

Answer 5

Surgeon Can’t See=>can’t surgically tx

Question 6

Describe the 5 A’s of SCLC

Answer 6

ACTH
siADH
Antibodies against pre synaptic Ca2+ (Lambert Eaton Syndrome)
Amplification of myc oncogenes
chromogranin A

Question 7

SCLC is of what endocrine origin?

Answer 7

Neuroendocrine

Question 8

A patient has a pneumonic coin lesion on CXR what is the next step?

Answer 8

Compare w/prior x-ray

Question 9

Squamous and SCLC are?

Answer 9

Sentral, Smoking, Paraneoplastic Syndrome

Question 10

MCC of Lung Cancer in Female smokers, nonsmokers and overall?

Answer 10

Adenocarcinoma

Question 11

Bronchioloalveolar subtype is most similar to?

Answer 11

Pneumonia

Question 12

Adenocarcinoma of Lungs means it produces? What does it stain for?

Answer 12

Glands and mucus production

Mucin+

Question 13

Adenocarcinoma has what kind of mutations?

Answer 13

Activating mutations including KRAS, EGFR, ALK

Question 14

Adenocarcinoma is associated with?

Answer 14

Hypertrophic osteoarthropathy (clubbing)

Question 15

Squamous Cell Carcinoma C’s?

Answer 15

Cavitation, Cigarettes, hyperCalcemia (produces PTHrP)

Question 16

Keratin pearls of intercellular bridges of desmosomes?

Answer 16

Squamous Cell Carcinoma

Question 17

Pleomorphic Giant Cells that is found in the periphery?

Answer 17

Large Cell Carcinoma

Question 18

well differentiated neuroendocrine cells that stain positive for chromogranin A and is a polyp like mass in the bronchus->?

Answer 18

Bronchial carcinoid tumor

Question 19

Most Lung Cancer is from?

Answer 19

Breast, Colon

Question 20

Where does Lung Cancer like to go to?

Answer 20

Adrenal Glands

Question 21

What is the main mutagen in Smoking?

Answer 21

polycyclic aromatic hydrocarbon

Question 22

Dilated vesels over neck and upper trunk?

Answer 22

SVC syndrome