Obstructive Lung Diseases

Question 1

A patient coughing up cups of mucus for more than 3 months per year for 2 years? Dx?

Answer 1

Chronic Bronchitis

Question 2

Patients with Chronic Bronchitis have 2 associated symptoms what are they?

Answer 2

Smoking and Cor Pulmonale

Question 3

Chronic Bronchitis MOA?

Answer 3

MOA: Hyperplasia of mucus glands=>reid index>50%

Question 4

Emphysema is balance problem between?

Answer 4

AAT and Elastase/Matrix Metalloprotease

Question 5

Emphysema Centriacinar is associated with?

Answer 5

Smoke

Question 6

Therefore, if centriacinar is associated with smoke, where is most often found?

Answer 6

Upper Lobe

Question 7

Emphysema Panacinar is associated with? Where is it found?

Answer 7

AAT-1 Def. Lower Lobe

Question 8

A patient who has pursed lips and a barreled chest. Dx?

Answer 8

Emphysema

Question 9

Emphysema MOA?

Answer 9

MOA: elastase destruction of elastic fibers=>alveolar collapse

Question 10

With Emphysema, you are turning a balloon into a?

Answer 10

Shopping Bag

Question 11

MC finding of Asthma?

Answer 11

Wheezing

Question 12

Allergen induces the Th2 cells to produce?

Answer 12

IL-4, IL-5 and IL-10

Question 13

Reexposure to allergen leads to?

Answer 13

Mast cells dumping preformed granules

Question 14

One of the granules that mast cells produce is histamine. What are two effects of histamine?

Answer 14

Vasodilation (arterioles) Increased vessel permeability (post-capillary venules)

Question 15

In an asthmatic patient, what two specific things will you see in the lungs?

Answer 15

Curshmann Spirals and Charcot-Leydren crystals

Question 16

Prolonged expiration with pursed lips=>why are people doing that?

Answer 16

To generate back pressure ot keep the air sacs opened

Question 17

Bronchiectasis MOA?

Answer 17

Aneurysm in the lungs=>air pools=> can’t get out=>walls bigger

Question 18

Bronchiectasis is associated with 3 things?

Answer 18

1. CF 2. Ciliary Motility 3. ABPA

Question 19

Bronchiectasis has 2 complications?

Answer 19

Secondary Amyloidosis (AA=>SAA) Increased risk of infections

Question 20

Hallmark of Obstructive diseases? FEV1/FVC? TLC?

Answer 20

FEV1/FVC ration is decreased TLC increased

Question 21

Answer 21

Curschmann Spirals

Question 22

Answer 22

Charcot-leyden crystals

Question 23

What words describe Obstructive diseases?

Answer 23

Interalveolar wall destruction

Question 24

In Obstructive Diseases, which chemoreceptors (central vs peripheral) more in control? In Healthy people?

Answer 24

In healthy people=> CO2=>Central

In obstructive=>O2=>Peripheral