Obstructive Lung Diseases Flashcards
A patient coughing up cups of mucus for more than 3 months per year for 2 years? Dx?
Chronic Bronchitis
Patients with Chronic Bronchitis have 2 associated symptoms what are they?
Smoking and Cor Pulmonale
Chronic Bronchitis MOA?
MOA: Hyperplasia of mucus glands=>reid index>50%
Emphysema is balance problem between?
AAT and Elastase/Matrix Metalloprotease
Emphysema Centriacinar is associated with?
Smoke
Therefore, if centriacinar is associated with smoke, where is most often found?
Upper Lobe
Emphysema Panacinar is associated with? Where is it found?
AAT-1 Def. Lower Lobe
A patient who has pursed lips and a barreled chest. Dx?
Emphysema
Emphysema MOA?
MOA: elastase destruction of elastic fibers=>alveolar collapse
With Emphysema, you are turning a balloon into a?
Shopping Bag
MC finding of Asthma?
Wheezing
Allergen induces the Th2 cells to produce?
IL-4, IL-5 and IL-10
Reexposure to allergen leads to?
Mast cells dumping preformed granules
One of the granules that mast cells produce is histamine. What are two effects of histamine?
Vasodilation (arterioles) Increased vessel permeability (post-capillary venules)
In an asthmatic patient, what two specific things will you see in the lungs?
Curshmann Spirals and Charcot-Leydren crystals
Prolonged expiration with pursed lips=>why are people doing that?
To generate back pressure ot keep the air sacs opened
Bronchiectasis MOA?
Aneurysm in the lungs=>air pools=> can’t get out=>walls bigger
Bronchiectasis is associated with 3 things?
- CF 2. Ciliary Motility 3. ABPA
Bronchiectasis has 2 complications?
Secondary Amyloidosis (AA=>SAA) Increased risk of infections
Hallmark of Obstructive diseases? FEV1/FVC? TLC?
FEV1/FVC ration is decreased TLC increased
Curschmann Spirals
Charcot-leyden crystals
What words describe Obstructive diseases?
Interalveolar wall destruction
In Obstructive Diseases, which chemoreceptors (central vs peripheral) more in control? In Healthy people?
In healthy people=> CO2=>Central
In obstructive=>O2=>Peripheral
