Respiratory Pharma Flashcards
MOA of salbutamol
stimulates adenylyl cyclase
MOA of theophylline
blocks adenosine
MOA of ipratropium
antimuscarinic
MOA of montelukast
blocks LTD4 receptor
MOA of cromoglycate
mast cell stabilizer
anti asthma drug best for quick relief of airway obstruction in acute asthma exacerbations with the greatest margin of safety… epinephrine, salbutamol, theophylline, or ipratropium
salbutamol
why is SABA and LABA not suitable as monotherapy drugs for asthma
because b2 agonists lang sila.. they do not have anti-inflammatory properties
the FDC SABA + ipratropium exhibits this type of drug interation
addition
bronchodilator of choice for patients with COPD and patients with poorly controlled asthma on high dose ICS-LABA
Tiotropium
which anti asthma drug possesses both bronchodilator and anti inflammatory properties… formoterol, montelukast, theophylline, or ipratropium
theophylline
administration of which of the following substance can enhance clearacne of theophylline: nicotine, grapefruit juice, macrolifes, or cimetidine
nicotine (smoke)
this add-on tyherapy to ICS LABA can be given to patients with “one airway disease”
montelukast. one airway disease pertains to patients with both AR and bronchial asthma
best anti asthma drug to reduce bronchial hyperreactivity of persistent asthma
ICS
the general safety of inhaled corticosteroid is due to what pharmacokinetic/pharmacodynamic property?
systemically absorbed ICS undergo 1st pass effect in the liver
FDC LABA + ICS exhibits this type of drug interaction
synergism. LABA enhances ICS deposition in the airway, ICS prevents dowregulation of B2 receptors
the ff steroid preparation is a pro drug. it’s C-11 ketone needs to be hydroxylated in the liver before it becomes active…. prednisone, prednisolone, methylprednisolone, or dexamethasone
prednisone
the renal excretion of the ff electrolytes are enhanced by corticosteroid except…. sodium , potassium, hydrogen, or calcium…
sodium (Na). may sodium retaning property kasi ang corticosteroids kaya nga nagkaka mineralocorticoid chorla effect siya chenes
effect of corticosteroid on neutrophils
it will increase the number of neutrophils (via demargination of neutrophils from the blood vessel wall )
the most potent mineralocorticosteroid recommended in the treatment of salt losing adrenogenital syndrome
fludrocortisone
in adopting “Every other day” steroid therapy for persistent severe asthma, which of the following is most suitable for long term use……. hydrocortisone, prednisone, dexamethasone , or fludrocortisone
prednisone