5HT2 antagonist used for: 1. pheochromocytoma 2. carcinoid syndrome 3. serotonin syndrome 4. cold urticaria 5. hypertension/vasopasm

1. phenoxybenzamine 2. cyproheptadine 3. cyproheptadine 4. cyproheptadine 5. ketanserin

Ratio 1st Shifting Even Flashcards by Dddddd Sssss

5HT1 antagonist used for anxiety/depression VERSUS acute migraine/cluster headache

anxiety/depression:
Buspirone

acute migraine/cluster headache:
Sumatriptan

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DOC for cluster headache

Sumatriptan

…a 5HT1 antagonist

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5HT2 antagonist used for:

pheochromocytoma
carcinoid syndrome
serotonin syndrome
cold urticaria
hypertension/vasopasm

phenoxybenzamine
cyproheptadine
cyproheptadine
cyproheptadine
ketanserin

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5HT4 agonist/partial agonist used for:

GERD
IBD with constipation

Cisapride

2. Tegaserod

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examples of vasoactive peptide with vasoconstrictor effect

AVENU:

angiotensin 2

vasopressin

endothelin

neuropeptide Y

uropeptides

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MOA of edrophonium

acetylcholinesterase inhibitor leading to increased acetycholine…

used as tx for myasthenia gravis

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muscarinic agonist used for glaucoma

pilocarpine

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cholinesterase inhibitor used for Alzheimer’s dsx

Donepezil

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example of a nonselective beta blocker that can cause bronchospasm

Propanolol

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selective beta2 agonist causing relaxation of bronchiolar smooth muscle used as a bronchodilator in asthma and tocolytic in premature labor

terbutaline

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selective alpha1 agonist also used as decongestant in rhinitis and colds

phelyephrine

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completely blocks alpha1 receptor used in the managment of malignant hypertension during operatioons for pheochromocytoma

phentolamine

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a competitive pharmacologic antagonist at all M receptors (nonselective) used to treat organophosphate toxicity

Atropine

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specific effects of parasympathetic drugs that leads to miosis

contraction of circular muscle of iris

and relaxation of radial muscle of iris

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what receptors are being stimulated leading to miosis

M3 receptors

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DOC for DM gastroparesis

metoclopramide

AED with SE of mild leukopenia, hyponatremia, and osteomalacia

Carbamazepine

AED with SE of gingival hyperplasia and folate deficiency

phenytoin

AED with SE of ataxia and diplopia

lamotrigine

AED that inhibits neurotransmission thru NMDA receptor antagonism vs AMPA/kainate receptor antagonismm

NMDA: Felbamate

AMPA/kainate: Topiramate

memonics for drugs for Alzheimers

Don Riva Gala has Alzheimers

DONepezil

RIVAstigmine

GALAntamine

**all are acetylcholinesterase inhibtors

The most appropriate drug for long term treatment of the disease is:

Pyridostigmine

Drug used to diagnose myasthenia gravis

Edrophonium

Sumatriptan that is used to treat acute severe migraine is contraindicated to px with…

coronary artery dsx bc of vasoconstrictive effect

first line drug for rheumatoid arthritis

Methotrexate

moa of methotrexate as a DMARD vs antineoplastic agent

As DMARD: inhibits thymidylate synthase and AICAR As Antineoplastic: inhibits dihydrofolate reductase

NSAID that is contraindicated in gout

Aspirin

apart from NSAID, what other drug is used to treat acute attacks of gout

Colchicine

DOC for acute attacks of gout vs chronic gout vs maintenance of gout

acute attack: NSAID, Colchicine chronic gout: Allopurinol maintenance: Allopurinol

anti-gout with the ff MOA: 1. inhibits microtubule function & synthesis 2. xanthine oxidase inhibitor 3. uricosuric; Inhibit renal tubular reabsorption of weak

Colchicine inhibits microtubule function & synthesis Allopurinol - xanthine oxidase inhibitor Probenecid uricosuric; Inhibit renal tubular reabsorption of weak acids

anti-gout that causes: 1. bloody diarrhea 2. SJS 3. bone marrow suppression

Colchicine -bloody diarrhea Allopurinol -SJS, bone marrow suppression

anti convulsants that are enzyme inductors vs enzyme inhibitors vs both

PURE INDUCERS: Carbamazepine Lamotrigine Phenytoin Phenobarbital [Kala mo pepe inducer pala] PURE INHIBITOR: Valproic acid [Ayaw ni Val] BOTH: Topiramate, oxcarbazepine [Two-timer si Topi & Oscar]

SSRI examples

Paroxetine, Fluoxetine, Escitalo/Citalopram, Sertraline [Xet,Xet,Talo si Ser. SiSiRain ko sya]

SNRI examples

Venlafaxine, Duloxetine | [SiNiRa ko yung fax machine sa dulo]

MAOI examples

MAO-A: Moclobemide (RIMA) MAO-B: Selegiline, Rasagiline Both [PIT]: Phenelzine, Isocarboxazid, Tranylcypromine

TCA examples

Imipramine, Clomipramine, Nortriptyline, Amitriptyline, Doxepin [Take Care Ah, naPRAMI yung TRIP ni DOC sepin]

NASA example

Mirtazapine

anticonvulsant that causes: 1. spina bifida, SJS, rash 2. Hirsutism, gingival Hyperplasia, Hydantoin syndrome (craniofacial anomaly) 3. sedation, irritability and hyperactivity in children 4. peripheral visual field defect

1. Carbamazepine - spina bifida, SJS, rash 2. Phenytoin - [HHH] Hirsutism, gingival Hyperplasia, Hydantoin syndrome (craniofacial anomaly) 3. Phenobarbital - sedation, irritability and hyperactivity in children 4. Vigabatrin - peripheral visual field defect