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zzzPHARMACOLOGY > Ratio 1st Shifting Even > Flashcards

Ratio 1st Shifting Even Flashcards

1
Q

5HT1 antagonist used for anxiety/depression VERSUS acute migraine/cluster headache

A

anxiety/depression:
Buspirone

acute migraine/cluster headache:
Sumatriptan

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2
Q

DOC for cluster headache

A

Sumatriptan

…a 5HT1 antagonist

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3
Q

5HT2 antagonist used for:

  1. pheochromocytoma
  2. carcinoid syndrome
  3. serotonin syndrome
  4. cold urticaria
  5. hypertension/vasopasm
A
  1. phenoxybenzamine
  2. cyproheptadine
  3. cyproheptadine
  4. cyproheptadine
  5. ketanserin
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4
Q

5HT4 agonist/partial agonist used for:

  1. GERD
  2. IBD with constipation
A
  1. Cisapride

2. Tegaserod

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5
Q

examples of vasoactive peptide with vasoconstrictor effect

A

AVENU:

angiotensin 2

vasopressin

endothelin

neuropeptide Y

uropeptides

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6
Q

MOA of edrophonium

A

acetylcholinesterase inhibitor leading to increased acetycholine…

used as tx for myasthenia gravis

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7
Q

muscarinic agonist used for glaucoma

A

pilocarpine

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8
Q

cholinesterase inhibitor used for Alzheimer’s dsx

A

Donepezil

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9
Q

example of a nonselective beta blocker that can cause bronchospasm

A

Propanolol

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10
Q

selective beta2 agonist causing relaxation of bronchiolar smooth muscle used as a bronchodilator in asthma and tocolytic in premature labor

A

terbutaline

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11
Q

selective alpha1 agonist also used as decongestant in rhinitis and colds

A

phelyephrine

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12
Q

completely blocks alpha1 receptor used in the managment of malignant hypertension during operatioons for pheochromocytoma

A

phentolamine

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13
Q

a competitive pharmacologic antagonist at all M receptors (nonselective) used to treat organophosphate toxicity

A

Atropine

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14
Q

specific effects of parasympathetic drugs that leads to miosis

A

contraction of circular muscle of iris

and relaxation of radial muscle of iris

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15
Q

what receptors are being stimulated leading to miosis

A

M3 receptors

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16
Q

DOC for DM gastroparesis

A

metoclopramide

17
Q

AED with SE of mild leukopenia, hyponatremia, and osteomalacia

A

Carbamazepine

18
Q

AED with SE of gingival hyperplasia and folate deficiency

19
Q

AED with SE of ataxia and diplopia

A

lamotrigine

20
Q

AED that inhibits neurotransmission thru NMDA receptor antagonism vs AMPA/kainate receptor antagonismm

A

NMDA: Felbamate

AMPA/kainate: Topiramate

21
Q

memonics for drugs for Alzheimers

A

Don Riva Gala has Alzheimers

DONepezil

RIVAstigmine

GALAntamine

**all are acetylcholinesterase inhibtors

22
Q

The most appropriate drug for long term treatment of the disease is:

A

Pyridostigmine

23
Q

Drug used to diagnose myasthenia gravis

A

Edrophonium

24
Q

Sumatriptan that is used to treat acute severe migraine is contraindicated to px with…

A

coronary artery dsx bc of vasoconstrictive effect

25
Q

first line drug for rheumatoid arthritis

A

Methotrexate

26
Q

moa of methotrexate as a DMARD vs antineoplastic agent

A

As DMARD: inhibits thymidylate synthase and AICAR

As Antineoplastic: inhibits dihydrofolate reductase

27
Q

NSAID that is contraindicated in gout

28
Q

apart from NSAID, what other drug is used to treat acute attacks of gout

A

Colchicine

29
Q

DOC for acute attacks of gout vs chronic gout vs maintenance of gout

A

acute attack: NSAID, Colchicine

chronic gout: Allopurinol

maintenance: Allopurinol

30
Q

anti-gout with the ff MOA:

  1. inhibits microtubule function & synthesis
  2. xanthine oxidase inhibitor
  3. uricosuric; Inhibit renal tubular reabsorption of weak
A

Colchicine
inhibits microtubule function & synthesis

Allopurinol
- xanthine oxidase inhibitor

Probenecid
uricosuric; Inhibit renal tubular reabsorption of weak acids

31
Q

anti-gout that causes:

  1. bloody diarrhea
  2. SJS
  3. bone marrow suppression
A

Colchicine
-bloody diarrhea

Allopurinol
-SJS, bone marrow suppression

32
Q

anti convulsants that are enzyme inductors vs enzyme inhibitors vs both

A

PURE INDUCERS: Carbamazepine Lamotrigine Phenytoin Phenobarbital [Kala mo pepe inducer pala]

PURE INHIBITOR: Valproic acid [Ayaw ni Val]

BOTH: Topiramate, oxcarbazepine [Two-timer si Topi & Oscar]

33
Q

SSRI examples

A

Paroxetine, Fluoxetine, Escitalo/Citalopram, Sertraline

[Xet,Xet,Talo si Ser. SiSiRain ko sya]

34
Q

SNRI examples

A

Venlafaxine, Duloxetine

[SiNiRa ko yung fax machine sa dulo]

35
Q

MAOI examples

A

MAO-A: Moclobemide (RIMA)
MAO-B: Selegiline, Rasagiline
Both [PIT]: Phenelzine, Isocarboxazid, Tranylcypromine

36
Q

TCA examples

A

Imipramine, Clomipramine, Nortriptyline, Amitriptyline, Doxepin
[Take Care Ah, naPRAMI yung TRIP ni DOC sepin]

37
Q

NASA example

A

Mirtazapine

38
Q

anticonvulsant that causes:

  1. spina bifida, SJS, rash
  2. Hirsutism, gingival Hyperplasia, Hydantoin syndrome (craniofacial anomaly)
  3. sedation, irritability and hyperactivity in children
  4. peripheral visual field defect
A
  1. Carbamazepine - spina bifida, SJS, rash
  2. Phenytoin - [HHH] Hirsutism, gingival Hyperplasia, Hydantoin syndrome (craniofacial anomaly)
  3. Phenobarbital - sedation, irritability and hyperactivity in children
  4. Vigabatrin - peripheral visual field defect

zzzPHARMACOLOGY (10 decks)

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