Autacoids

Question 1

H1 blockers act as ____ agonist which has a preferential affinity of the inactive state, stabilizing the receptor in this conformation and consequently inducing an inactive state characterized by blocked signal transduction

Answer 1

inverse agonist

Question 2

anti histamine used to counter the EPS brought by antipsychotics

Answer 2

diphenhydramine

Question 3

ingestion of ergot alkaloid can lead to this complication characterized by dementia, florid hallucinations, prolong painful vasopasms leading to gangreme, and stimulation of uterine smooth muscles

Answer 3

St. Anthony’s fire

Question 4

Ergonovine, ergotamine, bromocriptine belong to what class of drug

Answer 4

ergot alkaloids

Question 5

vasoactive peptides that are vasoconstrictors (the rest are vasodilators)

Answer 5

AVENU: angiotensin II, vasopressin, endothelin, neuropeptide Y, urotensins

Question 6

which can pass thru BBB, 1st gen H1 blockers or 2nd gen

Answer 6

1st gen

Question 7

ARBs specifically act on what type of angiontensin receptor

Answer 7

AT1

Question 8

coxibs are known to inhibit what specific type of COX receptor

Answer 8

COX2

Question 9

prostanoid that is used to maintain patency of ductus arteriosus in cyanotic congenital heart disease

Answer 9

alprostadil

Question 10

prostanoid used for open angle glaucoma

Answer 10

latanoprost

Question 11

prostanoid used for treatment of pulmonary HPN and portopulmonary HTN

Answer 11

Eporostenol

Question 12

which of the following H1 blockers can be given safely and once daily to a pilot…….. clemastine, hydroxyzine, loratadine, or chlorphenamine?

Answer 12

Loratadine

Question 13

which of the following H1 blockers has adverse drug interactions with ketoconazole

Answer 13

Terfenadine

Question 14

a child has a history of motion sickness. What can you give her before her plane flight…… cetirizine,meclizine, chlorpheniramine, or loratadine?

Answer 14

meclizine

Question 15

which of the following H1 blockers is available as topical nasal spray for the tx of allergic rhinitis………. cetirizine, meclozine, azelastine, or loratadine?

Answer 15

azelastine

Question 16

which of the ff serotonin agonists is useful for the treatment of acute migraine……… buspirone, sumatriptan, cisapride, or fluoxetine

Answer 16

sumatriptan

Question 17

which of the ff serotonin agonists is useful for prophylaxis against nausea and vomiting induced by cancer chemotherapy

Answer 17

ondansetron

Question 18

this acts a a dopamine agonist and is useful in the treatment of hyperprolactinemia and parkinson disease……… bromocriptine, ergotamine, ergonovine, or methylsergide

Answer 18

bromocriptine

Question 19

how can ACEi induce severe cough

Answer 19

ACEIs inhibit the breakdown of kinins, enkephalines, and substance P which enhance cough reflex