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zzzPHARMACOLOGY > Anti TB, Anti Fungal, Anti Viral, Anti Malarial, Anti Protozoal > Flashcards

Anti TB, Anti Fungal, Anti Viral, Anti Malarial, Anti Protozoal Flashcards

1
Q

Anti tb drug that inhibits mycolic acid

A

Isoniazid

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2
Q

Anti tb drug that inhibits DNA dependent RNA polymerase

A

Rifampicin

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3
Q

Anti tb drug that disrupts cell membrane metabolism and transport functions

A

Pyrazinamide

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4
Q

Anti tb drug that inhibits arabinosyl transferase

A

Ethambutol

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5
Q

Anti tb drug that inhibits protein synthesis by binding to 30s ribosomal unit

A

Streptomycin

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6
Q

Which primary anti tb drug is most effective against rapidly growing extracellular (neutral ph) bacteria

A

Isoniazid

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7
Q

Which primary anti tb drug is most effective against slowly growing extracellular (neutral ph) bacteria

A

Rifampicin

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8
Q

Which primary anti tb drug is most effective against slowly growing intracellular (acidic ph) bacteria

A

Pyrazinamide

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9
Q

Which primary anti tb drug has no effect on slowly growing extracellular (neutral ph) bacteria

A

Pyrazinamide and ethambutol

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10
Q

Which primary anti tb drug has no effect on rapidly growing extracellular (neutral ph) bacteria

A

Pyrazinamide

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11
Q

Resistance to this anti tb drug involves inhA, katG, aphc, and kasA genes

A

Isoniazid

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12
Q

Resistance to this anti tb drug involves rpo B gene

A

Rifampicin

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13
Q

Resistance to this anti tb drug involves pncA gene

A

Pyrazinamide

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14
Q

Resistance to this anti tb drug involves emb B gene

A

Ethambutol

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15
Q

Most potent sterilizing anti tb drug

A

Rifampicin

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16
Q

Anti tb drug that causes peripheral neuropathy, seizures, hepatotoxicity, hemolysis in G6PD , drug induced lupus

A

Isoniazid

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17
Q

Anti tb drug that causes discoloration of body fluids (red orange) , thromobcytopenia

A

Rifampicin

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18
Q

Anti tb drug that causes hyperuri emia

A

Pyrazinamide

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19
Q

Anti tb drug that causes retrobulbar neuritis, hyperuiricemia

A

Ethambutol

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20
Q

DOC for non falciparum and sensitive falciparum malaria

A

Chloroquine

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21
Q

anti malarial drug that can be used as treatment for rheumatic disease

A

chloroquine

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22
Q

anti malarial drug with adverse effect of cinchonism charac by tinnitus, headache, dizziness, vomiting, flushing, visual disturbances

A

Quinine/quinidine

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23
Q

anti malarial drug with AE of blackwater fever

A

quinine/quinidine

24
Q

anti malarial drug with AE of psychosis

A

mefloquine

25
Q

anti malarial drug that can be used for radical cure of p. vivax and p. ovale

A

primaquine

26
Q

most common AE of primaquine

A

hemolytic anemia or methemoglobinermia in G6PD deficiency

27
Q

DOC in the tx of all symptomatic amebiasi

A

Metronidazole

28
Q

DOC in the tx of giardiasis

A

Metronidazole

29
Q

DOC in the trichomoniasis

A

Metronidazole

30
Q

DOC in Clostridium difficile-induced pseudomembranous colitis

A

Metronidazole

31
Q

anti-helminth used for annual deworming of Filipino children 1 to 14 years of age

A

Albendazole

32
Q

DOC for hydatid cyst

A

Albendazole

33
Q

DOC for neurocysticercosis (in combination with steroids)

A

Albendazole

34
Q

DOC for cutaneous and visceral larva migrans

A

Albendazole

35
Q

DOC for intestinal capillariasis

A

Albendazole

36
Q

Anti-helminth that inhibit microtubule polymerization by binding to the parasite’s beta tubulin, thus interfering with microtubule-dependent glucose uptake by the parasite leading to glycogen consumption and ATP depletion

A

Albendazole

37
Q

anti-helminth that depolarizes the NMJ of most intestinal nematodes resulting in their irreversible paralysis and allowing their natural expulsion

A

Pyrantel pamoate

38
Q

DOC for filariasis

A

DEC - diethylcarbamazine citrate

39
Q

DOC for loaiasis

A

DEC - diethylcarbamazine citrate

40
Q

Mazzoti reaction is AE of what drug

A

DEC - diethylcarbamazine citrate and Praziquantel

41
Q

anti-helminth that immobilizes microfilariae and alters their surface structure, displacing them from tissues and making them more susceptible to destruction by host defense mechanisms

A

DEC - diethylcarbamazine citrate

42
Q

anti-helminth that paralyzes the parasite by intesifying GABA-mediated transmission of signals in the parasite’s peripheral nerves

A

Ivermectin

43
Q

DOC for onchocerciasis

A

Ivermectin

44
Q

DOC for strongyloidiasis

A

Ivermectin

45
Q

anti-helminth that increases the permeability of trematod and cestode cell membrane to calcium resulting to spastic paralysis and death

A

Praziquantel

46
Q

DOC for schistosomiasis

A

Praziquantel

47
Q

DOC for H. nana infection

A

Praziquantel

48
Q

Chemoprophylactic drug for malaria for areas without resistant P. falciparum

A

Chloroquine

49
Q

Chemoprophylactic drug for malaria for areas with chloroquine-resistant P. falciparum

A

Atovaquone-proguanil (Malarone) ORRRRRR Mefloquine

50
Q

Chemoprophylactic drug for malaria for areas with MDR P. falciparum

A

Doxycycline

51
Q

This antibiotic can be used for treatment of malaria. It is usually given together with quinine

A

Doxycycline

52
Q

DOC for asymptomatic intestinal amebic infections

A

Diloxanide furoate

53
Q

DOC for symptomatic amebic infection (regardless of severity)

A

Metronidazole + Diloxanide furoate

54
Q

DOC for early stage West VERSUS East African trypanosomiasis

A

West: Pentamidine
East: Suramin

55
Q

Treatment for acute American trypanosomiasis (Chaga’s disease)

A

Nifurtimox

zzzPHARMACOLOGY (10 decks)

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