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zzzPHARMACOLOGY > Ratio 4th Shifting Even > Flashcards

Ratio 4th Shifting Even Flashcards

1
Q

Anthracycline that is the only heart friendly

A

Epirubicin

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2
Q

2 Leukemogenic Antineoplastics

A
  1. Alkylating Agents

2. Topoisomerase II inhibitors

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3
Q

A 15 year old teen was diagnosed with Acute Myelogenous Leukemia. The most appropriate anti-neoplastic to give is:

A

Cytarabine

**Cytarabine- AML
C-AMeL

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4
Q

antineoplastic for CLL

A

Fludarabine

**CaLL the doctor, may FLU

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5
Q

A 50 y/o female with Graves’ disease developed tonsillopharyngitis. On PE, she is tachycardia, with fever, chills, and diarrhea. What is the best single drug to give for more rapid control of her symptoms?

A

PTU!!!

Top two choices would be Methimazole and PTU, but take note of the keywords: RAPID CONTROL!

  • PTU has RAPID dose response
  • Methimazole has SLOW dose response
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6
Q

antineoplastic drug that can kill all cells in all stages of the cell cycle

A

Cisplatin

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7
Q

Drug that can cause Ebstein anomaly vs Moebius sequence

A

Ebstein: lithium

Moebius: Misoprostol

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8
Q

Drug that can cause fetal hydantoin syndrome

A

phenytoin

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9
Q

adverse effect of isotretinoin on fetus

A

cardiac, ear, and clefting defects

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10
Q

MOA of etoposide vs topotecan

A

topotecan: topoisomerase I inhhibitor
etoposide: [topoisomerase 2 inhibitor

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11
Q

anti-osteoporotic drug that can cause hypercoagulable state

A

Raloxifene (SERM)

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12
Q

anti-osteoporotic drug that can cause hypercalcemia and osteosarcoma

A

Teriparatide

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13
Q

anti-osteoporotic drug that can cause subtrochanteric fx

A

alendronate (bisphosphonate) and denosumab

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14
Q

anti-osteoporotic drug that can cause osteonecrosis of jaw

A

alendronate (bisphosponate)

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15
Q

ADR of asparagine

A

neurotoxicity

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16
Q

ADR of cisplatin

A

ototoxic/nephrotoxic

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17
Q

tx for cisplatin toxicity

A

amifostine

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18
Q

ADR of vincristine vs vinblastine

A

vincristine: peripheral neuropathy
vinblastine: myelosuppression

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19
Q

ADR of bleomycin

A

pulmonary fibrosis

20
Q

ADR of doxorubicin

A

cardiotoxicity

**Tx is Dexrozane

21
Q

ADR of cyclophosphamide

A

nephro/bladder toxicity

Tx: MESNA

22
Q

Cyclophosphamide can cause SIADH.. what is the tx

A

Demeclocycline

23
Q

tx for nephrotoxicity due to Methotrexate

A

Leucovirin

24
Q

A patient with ALL underwent induction chemotherapy. He developed constipation for 4 days and was given laxatives to no relief. The condition progressed to obstipation and paralytic ileus. The agent that likely caused this is:

A 
Vincristine belly – obstipation and paralytic ileus due to autonomic neuropathy (given in high doses)
Has SENSORY (stocking and glove), MOTOR (foot drop) and AUTONOMIC AE
25
Q

60 year old patient with hypercalcemia due to renal insufficiency was diagnosed to have osteoporosis on bone densitometry. The most suitable treatment for her is:

A

Denosumab does not need any dose adjustment for decreased kidney function unlike risedronate which should be limited to those with GFR >30-35 mL/min.

26
Q

group of antibiotic that can cause 8th cranial nerve toxicitiy (ototoxic)

A

aminoglycosides (gentamicin, etc)

27
Q

A 50 year old bank manager with lung cancer was given antineoplastic agent for which se developed arrhythmia, conduction abnormalities and myocarditis. The agent that could have caused these problems is most likely:

A

Doxorubicin

28
Q

where is endogenous vs exogenous insuline cleared…

A

exogenous: kidney primarily
endogenous: liver primarily

**but can be clearedd by both organs

29
Q

drugs that increase insulin sensitivity

A

Metformin and TZDs

30
Q

anti-DM group of drug that is biliary excreted

A

DPP4 inhibitor (sitagliptin)

31
Q

insulin that is has acidic pH in solution

A

insulin glargine

32
Q

insulin that has fatty acid side chain

A

Detemir

**myristic acid is added to B29 lysine

33
Q

anti-DM drug that can cause lactic acidosis

A

Metformin

34
Q

anti-DM that can cause weight loss

A

SGLT2 inhibitors (-gliflozin)

35
Q

anti-DM that is injected SQ (except for insulin)

A

GLP1 agonist)

36
Q

This hormone can be given in order to test for hypogonadism

A

GnRH analogue

37
Q

A 35 year old on her 25th wk of gestation was prescribed a medication to stop her contractions. She accidentally doubled the dose and is now experiencing tachycardia, headache, nervousness and anxiety. She most likely took:

A

Salbutamol

38
Q

37 year old on her 30th week AOG is having preterm labor. She suddenly feels warm with nausea, vomiting, and dryness of mouth. The most probable tocolytic given to this patient is

A

SE of Magnesium sulfate: Feeling of warmth, nausea, vomiting, dry mouth, blurred vision and transient hypotension.

39
Q

This anti estrogen inhibits aromaization of androgen to estradiol

A

Anastrazole

40
Q

antidote for:

  1. mercury
  2. lead
  3. paracetamol
  4. benzodiazepine
  5. copper
A
  1. Mercury: Succimer (DMSA)
  2. Lead: EDTA
  3. Paracetamol: NAC
  4. Benzodiazepine: Flumazenil
  5. Copper : penicillamine
41
Q

used to stimulate spermatogenesis in males with isolated gonadotropin deficiency

A

menotropin (gonadotropin)

42
Q

Dose limiting toxicity of:

  1. cytarabine
  2. cisplatin
  3. methotrexate
  4. bleomycin
  5. oxaliplatin
A
  1. cytarabine: myelosuppression
  2. cisplatin: nephrotoxicity
  3. methotrexate: myelosuppression
  4. bleomycin: pulmonary fibrosis
  5. oxaliplatin: nephrotoxicity
43
Q

Antiosteoportic that…

  1. Induces apoptosis of osteoclast
  2. Blocks binding of RANK ligand to its receptor
  3. Stimulates osteoblast formation
  4. Inhibits mevalonic acid important in osteoclast survival
A
  1. Raloxifene
  2. Denosumab
  3. Teriparatide
  4. Alendronate
44
Q

antidote for anti-cholinergic poisoning

A

physostigmine

45
Q

antidote for salicylate poisoning

A

IV sodium bicarbonate

46
Q

antiosteoporotic drug used for acute pain relief in patients with vertebral fracture

A

salmon calcitonin

zzzPHARMACOLOGY (10 decks)

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