Ratio 4th Shifting Even Flashcards
Anthracycline that is the only heart friendly
Epirubicin
2 Leukemogenic Antineoplastics
- Alkylating Agents
2. Topoisomerase II inhibitors
A 15 year old teen was diagnosed with Acute Myelogenous Leukemia. The most appropriate anti-neoplastic to give is:
Cytarabine
**Cytarabine- AML
C-AMeL
antineoplastic for CLL
Fludarabine
**CaLL the doctor, may FLU
A 50 y/o female with Graves’ disease developed tonsillopharyngitis. On PE, she is tachycardia, with fever, chills, and diarrhea. What is the best single drug to give for more rapid control of her symptoms?
PTU!!!
Top two choices would be Methimazole and PTU, but take note of the keywords: RAPID CONTROL!
- PTU has RAPID dose response
- Methimazole has SLOW dose response
antineoplastic drug that can kill all cells in all stages of the cell cycle
Cisplatin
Drug that can cause Ebstein anomaly vs Moebius sequence
Ebstein: lithium
Moebius: Misoprostol
Drug that can cause fetal hydantoin syndrome
phenytoin
adverse effect of isotretinoin on fetus
cardiac, ear, and clefting defects
MOA of etoposide vs topotecan
topotecan: topoisomerase I inhhibitor
etoposide: [topoisomerase 2 inhibitor
anti-osteoporotic drug that can cause hypercoagulable state
Raloxifene (SERM)
anti-osteoporotic drug that can cause hypercalcemia and osteosarcoma
Teriparatide
anti-osteoporotic drug that can cause subtrochanteric fx
alendronate (bisphosphonate) and denosumab
anti-osteoporotic drug that can cause osteonecrosis of jaw
alendronate (bisphosponate)
ADR of asparagine
neurotoxicity
ADR of cisplatin
ototoxic/nephrotoxic
tx for cisplatin toxicity
amifostine
ADR of vincristine vs vinblastine
vincristine: peripheral neuropathy
vinblastine: myelosuppression
ADR of bleomycin
pulmonary fibrosis
ADR of doxorubicin
cardiotoxicity
**Tx is Dexrozane
ADR of cyclophosphamide
nephro/bladder toxicity
Tx: MESNA
Cyclophosphamide can cause SIADH.. what is the tx
Demeclocycline
tx for nephrotoxicity due to Methotrexate
Leucovirin
A patient with ALL underwent induction chemotherapy. He developed constipation for 4 days and was given laxatives to no relief. The condition progressed to obstipation and paralytic ileus. The agent that likely caused this is:
Vincristine belly – obstipation and paralytic ileus due to autonomic neuropathy (given in high doses) Has SENSORY (stocking and glove), MOTOR (foot drop) and AUTONOMIC AE
60 year old patient with hypercalcemia due to renal insufficiency was diagnosed to have osteoporosis on bone densitometry. The most suitable treatment for her is:
Denosumab does not need any dose adjustment for decreased kidney function unlike risedronate which should be limited to those with GFR >30-35 mL/min.
group of antibiotic that can cause 8th cranial nerve toxicitiy (ototoxic)
aminoglycosides (gentamicin, etc)
A 50 year old bank manager with lung cancer was given antineoplastic agent for which se developed arrhythmia, conduction abnormalities and myocarditis. The agent that could have caused these problems is most likely:
Doxorubicin
where is endogenous vs exogenous insuline cleared…
exogenous: kidney primarily
endogenous: liver primarily
**but can be clearedd by both organs
drugs that increase insulin sensitivity
Metformin and TZDs
anti-DM group of drug that is biliary excreted
DPP4 inhibitor (sitagliptin)
insulin that is has acidic pH in solution
insulin glargine
insulin that has fatty acid side chain
Detemir
**myristic acid is added to B29 lysine
anti-DM drug that can cause lactic acidosis
Metformin
anti-DM that can cause weight loss
SGLT2 inhibitors (-gliflozin)
anti-DM that is injected SQ (except for insulin)
GLP1 agonist)
This hormone can be given in order to test for hypogonadism
GnRH analogue
A 35 year old on her 25th wk of gestation was prescribed a medication to stop her contractions. She accidentally doubled the dose and is now experiencing tachycardia, headache, nervousness and anxiety. She most likely took:
Salbutamol
37 year old on her 30th week AOG is having preterm labor. She suddenly feels warm with nausea, vomiting, and dryness of mouth. The most probable tocolytic given to this patient is
SE of Magnesium sulfate: Feeling of warmth, nausea, vomiting, dry mouth, blurred vision and transient hypotension.
This anti estrogen inhibits aromaization of androgen to estradiol
Anastrazole
antidote for:
- mercury
- lead
- paracetamol
- benzodiazepine
- copper
- Mercury: Succimer (DMSA)
- Lead: EDTA
- Paracetamol: NAC
- Benzodiazepine: Flumazenil
- Copper : penicillamine
used to stimulate spermatogenesis in males with isolated gonadotropin deficiency
menotropin (gonadotropin)
Dose limiting toxicity of:
- cytarabine
- cisplatin
- methotrexate
- bleomycin
- oxaliplatin
- cytarabine: myelosuppression
- cisplatin: nephrotoxicity
- methotrexate: myelosuppression
- bleomycin: pulmonary fibrosis
- oxaliplatin: nephrotoxicity
Antiosteoportic that…
- Induces apoptosis of osteoclast
- Blocks binding of RANK ligand to its receptor
- Stimulates osteoblast formation
- Inhibits mevalonic acid important in osteoclast survival
- Raloxifene
- Denosumab
- Teriparatide
- Alendronate
antidote for anti-cholinergic poisoning
physostigmine
antidote for salicylate poisoning
IV sodium bicarbonate
antiosteoporotic drug used for acute pain relief in patients with vertebral fracture
salmon calcitonin