Ratio 4th Shifting Even

Question 1

Anthracycline that is the only heart friendly

Answer 1

Epirubicin

Question 2

2 Leukemogenic Antineoplastics

Answer 2

1. Alkylating Agents

2. Topoisomerase II inhibitors

Question 3

A 15 year old teen was diagnosed with Acute Myelogenous Leukemia. The most appropriate anti-neoplastic to give is:

Answer 3

Cytarabine

**Cytarabine- AML
C-AMeL

Question 4

antineoplastic for CLL

Answer 4

Fludarabine

**CaLL the doctor, may FLU

Question 5

A 50 y/o female with Graves’ disease developed tonsillopharyngitis. On PE, she is tachycardia, with fever, chills, and diarrhea. What is the best single drug to give for more rapid control of her symptoms?

Answer 5

PTU!!!

Top two choices would be Methimazole and PTU, but take note of the keywords: RAPID CONTROL!

• PTU has RAPID dose response
• Methimazole has SLOW dose response

Question 6

antineoplastic drug that can kill all cells in all stages of the cell cycle

Answer 6

Cisplatin

Question 7

Drug that can cause Ebstein anomaly vs Moebius sequence

Answer 7

Ebstein: lithium

Moebius: Misoprostol

Question 8

Drug that can cause fetal hydantoin syndrome

Answer 8

phenytoin

Question 9

adverse effect of isotretinoin on fetus

Answer 9

cardiac, ear, and clefting defects

Question 10

MOA of etoposide vs topotecan

Answer 10

topotecan: topoisomerase I inhhibitor
etoposide: [topoisomerase 2 inhibitor

Question 11

anti-osteoporotic drug that can cause hypercoagulable state

Answer 11

Raloxifene (SERM)

Question 12

anti-osteoporotic drug that can cause hypercalcemia and osteosarcoma

Answer 12

Teriparatide

Question 13

anti-osteoporotic drug that can cause subtrochanteric fx

Answer 13

alendronate (bisphosphonate) and denosumab

Question 14

anti-osteoporotic drug that can cause osteonecrosis of jaw

Answer 14

alendronate (bisphosponate)

Question 15

ADR of asparagine

Answer 15

neurotoxicity

Question 16

ADR of cisplatin

Answer 16

ototoxic/nephrotoxic

Question 17

tx for cisplatin toxicity

Answer 17

amifostine

Question 18

ADR of vincristine vs vinblastine

Answer 18

vincristine: peripheral neuropathy
vinblastine: myelosuppression

Question 19

ADR of bleomycin

Answer 19

pulmonary fibrosis

Question 20

ADR of doxorubicin

Answer 20

cardiotoxicity

**Tx is Dexrozane

Question 21

ADR of cyclophosphamide

Answer 21

nephro/bladder toxicity

Tx: MESNA

Question 22

Cyclophosphamide can cause SIADH.. what is the tx

Answer 22

Demeclocycline

Question 23

tx for nephrotoxicity due to Methotrexate

Answer 23

Leucovirin

Question 24

A patient with ALL underwent induction chemotherapy. He developed constipation for 4 days and was given laxatives to no relief. The condition progressed to obstipation and paralytic ileus. The agent that likely caused this is:

Answer 24

Vincristine belly – obstipation and paralytic ileus due to autonomic neuropathy (given in high doses)
Has SENSORY (stocking and glove), MOTOR (foot drop) and AUTONOMIC AE

Question 25

60 year old patient with hypercalcemia due to renal insufficiency was diagnosed to have osteoporosis on bone densitometry. The most suitable treatment for her is:

Answer 25

Denosumab does not need any dose adjustment for decreased kidney function unlike risedronate which should be limited to those with GFR >30-35 mL/min.

Question 26

group of antibiotic that can cause 8th cranial nerve toxicitiy (ototoxic)

Answer 26

aminoglycosides (gentamicin, etc)

Question 27

A 50 year old bank manager with lung cancer was given antineoplastic agent for which se developed arrhythmia, conduction abnormalities and myocarditis. The agent that could have caused these problems is most likely:

Answer 27

Doxorubicin

Question 28

where is endogenous vs exogenous insuline cleared...

Answer 28

exogenous: kidney primarily endogenous: liver primarily **but can be clearedd by both organs

Question 29

drugs that increase insulin sensitivity

Answer 29

Metformin and TZDs

Question 30

anti-DM group of drug that is biliary excreted

Answer 30

DPP4 inhibitor (sitagliptin)

Question 31

insulin that is has acidic pH in solution

Answer 31

insulin glargine

Question 32

insulin that has fatty acid side chain

Answer 32

Detemir **myristic acid is added to B29 lysine

Question 33

anti-DM drug that can cause lactic acidosis

Answer 33

Metformin

Question 34

anti-DM that can cause weight loss

Answer 34

SGLT2 inhibitors (-gliflozin)

Question 35

anti-DM that is injected SQ (except for insulin)

Answer 35

GLP1 agonist)

Question 36

This hormone can be given in order to test for hypogonadism

Answer 36

GnRH analogue

Question 37

A 35 year old on her 25th wk of gestation was prescribed a medication to stop her contractions. She accidentally doubled the dose and is now experiencing tachycardia, headache, nervousness and anxiety. She most likely took:

Answer 37

Salbutamol

Question 38

37 year old on her 30th week AOG is having preterm labor. She suddenly feels warm with nausea, vomiting, and dryness of mouth. The most probable tocolytic given to this patient is

Answer 38

SE of Magnesium sulfate: Feeling of warmth, nausea, vomiting, dry mouth, blurred vision and transient hypotension.

Question 39

This anti estrogen inhibits aromaization of androgen to estradiol

Answer 39

Anastrazole

Question 40

antidote for: 1. mercury 2. lead 3. paracetamol 4. benzodiazepine 5. copper

Answer 40

1. Mercury: Succimer (DMSA) 2. Lead: EDTA 3. Paracetamol: NAC 4. Benzodiazepine: Flumazenil 5. Copper : penicillamine

Question 41

used to stimulate spermatogenesis in males with isolated gonadotropin deficiency

Answer 41

menotropin (gonadotropin)

Question 42

Dose limiting toxicity of: 1. cytarabine 2. cisplatin 3. methotrexate 4. bleomycin 5. oxaliplatin

Answer 42

1. cytarabine: myelosuppression 2. cisplatin: nephrotoxicity 3. methotrexate: myelosuppression 4. bleomycin: pulmonary fibrosis 5. oxaliplatin: nephrotoxicity

Question 43

Antiosteoportic that... 1. Induces apoptosis of osteoclast 2. Blocks binding of RANK ligand to its receptor 3. Stimulates osteoblast formation 4. Inhibits mevalonic acid important in osteoclast survival

Answer 43

1. Raloxifene 2. Denosumab 3. Teriparatide 4. Alendronate

Question 44

antidote for anti-cholinergic poisoning

Answer 44

physostigmine

Question 45

antidote for salicylate poisoning

Answer 45

IV sodium bicarbonate

Question 46

antiosteoporotic drug used for acute pain relief in patients with vertebral fracture

Answer 46

salmon calcitonin