respiratory cell biology Flashcards
respiratory mucosa: recall the structure and function of the respiratory mucosa throughout the respiratory tract, including the muco-ciliary escalator
what 3 cells is respiratory mucosa comprised of
ciliated cells, goblet cells, submucosal glands
features of ciliated cells
many mitochondria to produce ATP for continuous beating
what do goblet cells contain
mucin granules for secretion
2 types of submucosal glands
mucous acini, serous acini
where are mucous acini located and what do they produce
closer to ducts and produce mucus
where are serous acini located and what do they produce
more distal and secrete antibacteials in an aqueous solution to wash more viscous mucus to collecting duct
functions of respiratory mucosa
secretion of protective lining; antioxidant, antiprotease, lysozyme synthesis and release; xenobiotic metabolism
structure of cilia
actin polymers in 9+2 arrangement; dyein arms and ATPase allow columns to slide over each other and bend cilia
ciliary beating
beat in metachronal rhythm to move leading edge of mucous before moving back to next field
muco-ciliary escalator
moves mucous containing irritants and microbes upwards to larger airways for clearance by coughing or ingestion
what three cells secrete mucous
goblet cells, club cells, type II pneumocytes
where is surfactant mucous stored in type II pneumocytes
lamellar bodies
what does phospholipid-rich surfactant do
stops lung collapsing
