Respiratory Biomarkers Flashcards
define a biomarker
a naturally occuring molecule, gene or characteristic by which a particular pathological or physiological process, disease, etc can be identified”
what are 2 long-standing important biomarkers
- using body temperature, presence of fever and regression of fever to outline efficacy of treatment
- using blood pressure and detection of hypertension as a guide for treatment
what are 3 reasons biomarkers are important?
- reduces harms from ineffective treatment
- increases benefits from effective treatments
- economics (cost efficieny etc)
what are the 6 different types of biomarkers?
- Risk
- Diagnostic
- Prognostic
- Predictive
- Drug response
- Monitoring
what is a risk biomarker
biomarker associated with an increased/decreased chance of developing a disease before individual gets it
what is a diagnostic biomarker?
a biomarker that allows identification of disease, ideally detects subclinical/presymptomatic disease
what is a prognostic biomarker?
a biomarker that estimates the risk of disease and if treatment is needed
what is a predictive biomarker
a biomarker that can predict which treatment has the highest chance of efficacy
what is a drug response biomarker
a biomarker that can allow us to assess the efficacy of treatment
what is a monitoring biomarker
a biomarker that allows us to assess the severity of a disease over time.
