Respiratory

Question 1

Beta-2 adrenergic agonists examples?

Answer 1

LABA, SABA

Question 2

Beta-2 adrenergic agonists MoA?

Answer 2

Smooth muscle relaxing in the lungs, dilation and opening of the airways, bronchodilation.

Question 3

SABA, LABA CI?

Answer 3

Hyperthyroidism, DM ketoacidosis risk, glaucoma, CVS disease (HF, HTN, CAD, arrhythmia), hypokalemia

Question 4

What are the side effects of SABA, LABA?

Answer 4

Anxiety and tremor

Ventricular arrhythmia

Question 5

SABA, LABA examples?

Answer 5

Salbutamol, albuterol, levalbuterol, salmeterol

Question 6

SABA and LABA I?

Answer 6

Bronchial asthma, hyperkalaemia, COPD

Question 7

Inhaled corticosteroid MoA?

Answer 7

Suppress airways inflammation

Switch off inflammatory genes –> reverse histone acetylation –> HDAC2 decrease

Question 8

Inhaled corticosteroid I?

Answer 8

Combination with B2AA (SABA/LABA) for asthma treatment

Question 9

Reslizumab mechanism of action?

Answer 9

IL-5 binding so decrease survival and activation of eosinophils

Question 10

Reslizumab I?

Answer 10

Treatment of severe asthma (>18YO)

Question 11

Leukotriene receptor antagonist (LTRA) - PO MoA?

Answer 11

Bronchodilatory and anti-inflammatory effect.

Question 12

LTRA indication?

Answer 12

Chronic asthma, allergic sinusitis

Question 13

LTRA CI?

Answer 13

Hepatic impairment