GI

Question 1

H2 receptor antagonist MoA?

Answer 1

Block histamine action on parietal cells so less stomach acid produced

Question 2

Nizatidine, famotidine, cimetidine examples of?

Answer 2

H2 receptor antagonist

Question 3

PPI receptor antagonist MoA?

Answer 3

Block H+-K+-ATPase inhibiting gastric acid secretion

Question 4

Lansoprazole, omeprazole, esomeprazole examples of?

Answer 4

PPI

Question 5

PPI CI and which drugs?

Answer 5

Osteoporosis high risk patients
Endoscopy - mask upper GI malignancy symptoms
Methotrexate, Clopidogrel, warfarin

Question 6

Infliximab MoA?

Answer 6

Blocks the action of TNF-alpha so disrupts inflammation

Question 7

Infliximab I?

Answer 7

Crohn’s, psoriasis, RA, IBD, UC, Spondyloarthritis

Question 8

Infliximab CI?

Answer 8

TB, HepB, L. monocytogenes, yeast/fungal infection, immunosuppressed, leukaemia, GBS

Question 9

Movicol MoA?

Answer 9

Osmotic laxative by acting in the colon to soften and bulk up stools and promotes bowel movement

Question 10

Movicol CI and I?

Answer 10

Constipation is the indication

Severe IBD, perforated gut wall are CI

Question 11

Loperamide (imodium) action?

Answer 11

Slow down the intestinal motility and water and electrolyte movement through the bowel

Question 12

Imodium indication?

Answer 12

IBS, ST-diarrhoea, LT-diarrhoea in Chron’s or UC

Question 13

Buscopan (hyscine butylbromide) MoA?

Answer 13

Anti-cholingeric smooth-muscle relaxing effect acting on muscarinic and nicotinic receptors

Question 14

Buscopan I?

Answer 14

IBS, period pain, stomach cramps

Question 15

Mesalamine MoA?

Answer 15

COX inhibitor so decrease in prostaglandins and decrease in colon inflam

Question 16

Why use mesalamine?

Answer 16

UC symptomatic relief and Crohn’s (IBD)