Endocrine

Question 1

Metformin mechanism of action?

Answer 1

Decrease gluconeogenesis

Increase glucose uptake and use in skeletal muscles

Question 2

Metformin CI and I?

Answer 2

CI - HF, acute MI

I - T2DM, T1DM, GDM

Question 3

Metformin lead to gain or lose weight?

Answer 3

Lose

Question 4

Sulphonylurea mechanism?

Answer 4

B cells to secrete insulin

Question 5

SU CI, I, gain or lose weight?

Answer 5

CI - pregnancy and breastfeeding
I - T2DM
Gain

Question 6

SU x2 examples?

Answer 6

Gliclazide, glipizide

Question 7

DPP4 inhibitor mechanism of action?

Answer 7

Inhibit DPP4 so increase effect of incretins so stimulate insulin secretion.

Question 8

DPP4 inhibitor I, example, gain or lose weight?

Answer 8

T2DM
Sitagliptin
Same weight

Question 9

Glitazone mechanism of action?

Answer 9

Enhance fatty acid uptake and glucose by increasing insulin sensitivity

Question 10

Glitazone CI, I, gain or lose weight?

Answer 10

HF due to fluid retention
T2DM
Weight gain

Question 11

Carbimazole mechanism of action?

Answer 11

Serve as substrate for TPO so reduce amount of TH produced by inhibiting and decreasing iodine into tyrosine molecular conversion.

Question 12

Carbimazole CI and I?

Answer 12

Acute pancreatitis

Hyperthyroidism