MSK - Rheumatology

Question 1

Sulfasalazine MoA?

Answer 1

Inhibition of prostaglandins (systemic and colon anti-inflammatory)

Question 2

Sulfasalazine CI?

Answer 2

Bowel and urinary obstruction

Question 3

Sulfasalazine I?

Answer 3

RA, UC, Chron’s, ankylosing spondylitis

Question 4

NSAIDS MoA?

Answer 4

Inhibit COX enzyme so decrease prostaglandins and so decrease inflammation

Question 5

Aspirin, Ibuprofen, diclofenac and celecoxib are examples of?

Answer 5

NSAIDs

Question 6

NSAIDs CI?

Think risk of, and pregnancy?

Answer 6

Risk of peptic ulceration
3rd trimester
High stomach bleed risk, HTN, kidney disease, asthma, HSR past

Question 7

Opiates MoA?

Answer 7

Inhibit NT release; bind to opioid receptor releasing analgesia (mu, delta, kappa)

Question 8

Opiates x3 CI?

Answer 8

Severe respiratory instability
Acute psychiatric instability
Uncontrolled suicide risk

Question 9

Opiate antagonist?

Answer 9

Naloxone

Question 10

Opiates examples?

Answer 10

Methadone, morphine, tramadol, diamorphine, codeine, fentanyl

Question 11

Ciclosporin MoA?

Answer 11

Inhibit the production of cytokines involved in regulation of T cell antibodies (interleukin 2 in particular)

Question 12

Ciclosporin CI?

Answer 12

Grapefruit juice, infection, hypercholesterolemia, cancer, malignancy, HTN.

Question 13

Ciclosporin use?

Answer 13

Organ transplant, nephrotic syndrome, psoriasis, UC, RA, atopic dermatitis

Question 14

Bisphosphonates MoA?

Answer 14

Inhibit osteoclastic bone resorption

Question 15

Risedonate, alendronate, ibandronate are examples of?

Answer 15

Bisphosphonates

Question 16

Paracetamol MoA?

Answer 16

Inhibit prostaglandin synthesis and activate the descending serotonergic pathway

Question 17

Paracetamol indication?

Answer 17

Pain relief

Question 18

When not to use Paracetamol?

Answer 18

Headache, muscle ache, arthritis, backache, cold, fever, toothache