Genitourinary + neuro (to complete when completed neuro run-through)

Question 1

Alpha blocker MoA?

Answer 1

Block effects of nerves in the SYMPA and relax smooth muscle of the bladder neck to improve urine flow

Question 2

Alpha-blocker I and CI?

Answer 2

BPH, HTN, ED, PTSD

Raynaud’s, GI obstruction

Question 3

Doxazosin, prazosin, terazosin, Tamsulosin are examples of, think SE and last in particular?

Answer 3

Alpha-blockers

Dizzy and decrease BP so postural hypotension.

Question 4

Viagra MoA?

SE?

Answer 4

Smooth muscle relaxation so increase the blood flow to the corpus cavernosum
Facial flush and red

Question 5

Oxybutynin MoA?

Answer 5

Suppress involuntary contractions of the bladder smooth muscles (detrusor muscles)

Question 6

Why use oxybutyin?

CI?

Answer 6

Overactive bladder and detrusor overactive

Urinary retention, poorly controlled glaucoma

Question 7

5 alpha-reductase inhibitors MoA?

CI so what?

Answer 7

Reduce the size of the prostate so use in BPH

Unprotected sex as excreted in the semen

Question 8

Anticholinergics such as atropen and belladonna alkaloids MoA?

Answer 8

Block Ach so block the impulses responsible for involuntary muscle movement (PARA)

Question 9

CI for anticholinergics?

Answer 9

Hyperthyroidism, myasthenia gravis, HTN, tachycardia

Question 10

Anticholinergics used for?

Answer 10

Asthma, overactive bladder, COPD, diarrhoea, dizziness/motion sickness

Question 11

What is the first line for Parkinson’s under age of 60 years old?
What is generally given otherwise and 2 others? Qz

Answer 11

DA agonist

Levodopa
COMT inhibitor, MAO inhibitor

Question 12

Tremor in MS give?

Answer 12

Beta-blocker

Question 13

Urinary issue in MS give?

Answer 13

Oxybutynin

Question 14

Fatigue in MS give?

Answer 14

Amantadine

Question 15

Ataxia and depression in MS give?

Answer 15

Walking aid, physio

SSRI

Question 16

Spasticity in MS give?

Answer 16

Baclofen, gabapentin

Question 17

What disease modifying drugs in MS would one give?

Answer 17

B-interferon, natalizumab, glatiramer acetate

Question 18

What should be given for acute MS relapses?

Answer 18

IV/PO methylprednisolone

Question 19

MND is never what?

Answer 19

Sensory or eye involvement

Question 20

What is the only drug given to MND that is really effective?

Answer 20

Riluzole - protect brain and spinal cord from too much glutamate

Question 21

Migraine prophylaxis?

Answer 21

Beta-blockers
Amitriptyline
Anticonvulsants
Botulinum toxin type A

Question 22

Cluster headache acute treatment?

Answer 22

100% oxygen, sumatriptan SC injection

Question 23

Cluster headache prophylaxis?

Answer 23

Lithium, verapimil (CCB)

Question 24

Trigeminal neuralgia x2 management?

Answer 24

Carbamazepine

Lamotrigine

Question 25

GCA treatment?

Answer 25

High dose prednisolone

Question 26

Give what for raised ICP and how does it work?

Answer 26

IV mannitol

Drives fluid from the brain/CSF to blood so decreases the intracranial volume

Question 27

Status epilepticus acute treatment?

As what?

Answer 27

Benzodiazepine
IV Lorazepam, IV phenytoin
Medical emergency

Question 28

Carbamazepine, phenytoin, ethosuximide, lamotrigine MoA?

Answer 28

Modulation of voltage gated ion channels

Sodium and calcium channel inhibitors

Question 29

Phenytoin CI?

Answer 29

Pregnancy

Question 30

Carbamazepine SE?

Answer 30

Water retention and poorer mental health

Question 31

Benzodiazepine MoA?

Answer 31

Enhancement of synaptic inhibition

Question 32

What should be considered with all Antiepileptic drugs?

Answer 32

Pregnancy as a CI due to teratogenic