resp onc 8

Question 1

HIV positive, feet swelling, brown purpuiric lesions over ankles… cd<300
diagnose and txt

Answer 1

Kaposi aids def illness

txt with interferon alpha

Question 2

interferon alpha can treat what

Answer 2

hep B C Kaposi

Question 3

pt presents with a right flank mass and hematuria ….. ct shows multiple foci in lungs too … tumor is removed and what txt shd be given after this ?

Answer 3

diag of RCC
recombinant IL2 should be given after RCC
IL2 is secreted by all T cells —– activates natural killers to get rid of other cancerous cells

Question 4

rituximab

Answer 4

monoclonal CD20 … B cell neoplasm

Question 5

aldesleukin

Answer 5

IL2 recombinant

Question 6

traztuzumab

Answer 6

this is an antibody against HER 2

Question 7

what can make a female patient with breast cancer and history of HER +ve breast cancer, hysterectomy a good candidate for tamoxifen therapy?

Answer 7

HYSTERECTOMY not the HER +ve
remember tamoxifen is SER selective estrogen receptor modulator that may also act as an agoinist in endometrium as for this woman she has no uterus so its OK
that can help with osteoperosis too as it blocks osteoclasts

Question 8

what is a case control study

Answer 8

group of ppl with the disease are compared with a grp of ppl with no disease

Question 9

homeless IV drug user … purple plaques …biopsy spindle shaped tumor cells

Answer 9

Kaposi HHV8

tumor of endothelial cells

Question 10

cisplatin mechanism and use

Answer 10

cross link DNA
used in testicular bladder ovarian and lung cancer
SE – nephrotxic prevent with amifostine (free radicle scavenger)

Question 11

horner syndrome

Answer 11

ipsilateral ptosis, anhidrosis and miosis

Question 12

most common lung cancer that can cause horner

Answer 12

adenocarcinoma

Question 13

pt has sulfa allergy and pneumocystits what would be the txt

Answer 13

atrovaquine

Question 14

5 month girl …. runny nose fever cough sneezing…..bilateral wheezing and ronchi

Answer 14

bronchiolitis
most common cause is RSV ss -ve sense RNA
RSV contains two surgace proteins G protein that enable sattachment and F protein that enables fusion

Question 15

pt has infection with crptococcus and after txt he presents with hypokalemia and hypomagnesemia
what could be the cause

Answer 15

txt with amphotericin

this can be an adverse reaction of amphotericin

Question 16

what allows cancer cells in DCIS to by pass the basememnt membrane

Answer 16

secretion of metalloproteases

Question 17

BCL2

Answer 17

antiapototic

Question 18

BAX

Answer 18

proapototic

Question 19

congenital diaphragmatic hernia can complicate into?

Answer 19

pulomary hypoplasia…. pulm hyprtension and this lead to increase PCWP >22mmhg

Question 20

40 yrs old man ,,,, muscle aches fever and Gi symtoms intitially … Colorado … as disease progressed the pt had signs of P edema

Answer 20

hantavirus … deer urine

Question 21

infected with a flavivirus

Answer 21

acute GI symptoms.. fever

Question 22

west nile

Answer 22

encephalitis GI disturbance

Question 23

txt for infec with H.influenza

Answer 23

amox…. ceftriaxone

Question 24

ulcerated lesion on lower lip

Answer 24

SCC

Question 25

Blastomyces dermatitidis is a fungus that is mostly found along

Answer 25

Mississippi River and in Central America

Question 26

beryliosis occupation

Answer 26

aerospace industrial equipment

Question 27

foundries and sandblasting

Answer 27

silicosis

Question 28

ollege students, who have a dry cough, headache, and dyspnea and diffuse patchy interstitial infiltrates

Answer 28

Mycoplasma pneumoniae. macrolide antibiotic

Question 29

macrolide antibiotic

Answer 29

Methylation of the 23S rRNA in resistant bacteria

Question 30

long term effects of IV roids

Answer 30

avascular necrosis, abdominal striae and increased girth, suppression of the hypothalamic-pituitary-adrenal axis, hyperglycemia, osteoporosis, moon facies, buffalo hump, immunosuppression, and impaired wound healing.

Question 31

hibits IgE binding FCeRI,

Answer 31

Omalizumab

Question 32

bilateral lower extremity weakness, spastic gait, back pain, and urinary incontinence.
hs an exudative eczematous rash affecting his scalp, axillae, and groin.
these symptoms were gradual

Answer 32

HTLV 1

characterized by myelin destruction within the spinal cord and brain

Question 33

streptococcal pharyngitis allergic to penicillin what is the txt

Answer 33

azithromycin macrolides

Question 34

hyper- and hypolucent areas, destruction of the cortex, with a rise in the periosteum

Answer 34

osteosarcoma

Question 35

helpful mnemonic for the characteristics of pneumonia caused by Klebsiella

Answer 35

Aspiration pneumonia, Abscess in lung and liver, Alcoholism, currAnt-jelly sputum, and diAbetes.

txt cefazolin
klebsiella is oxidase -