resp onc 2

Question 1

pt with LHF … increased diastolic pressure

what happens to elastic recoil

Answer 1

increase recoil … decrease compliance

Question 2

what does spontaneous pneumothorax do to all the lung capacities

Answer 2

DECREASE

Question 3

what is vital capacity

Answer 3

total amount of air that can be exhaled

Question 4

inc FRC inc TLC but decreased vital capacity

Answer 4

obstructive disease

Question 5

biopsy of spleen reveals lymph node like structure with abnormal germinal centers ….+ve for CD 20 and BCL2

Answer 5

follicular lymphoma … t (14,18

Question 6

overexpression of cyclin D

Answer 6

Mantle cell lymphoma … t (11,14)

Question 7

B cell neoplasm …. overproduction of igM…. nose bleeds due to damaged vessels … igM increases viscocity of blood

Answer 7

waldernstrom macroglobulenemia

Question 8

protein A binds Fc portion

Answer 8

staph aureus

Question 9

moleculre mimicry caused by which virulence factor

Answer 9

M protein

Question 10

zileuton mechanism

Answer 10

bock conversion of arachidonic acid to lipoxygenase 5

Question 11

moteleukast

Answer 11

inhibit the leukotriene receptors

Question 12

what is rb gene and how does it play a role in cancer devp

Answer 12

it is a tumor suppressor gene that normally inactivates E2F

Question 13

pancreatic cancer gene mutation

Answer 13

p16

Question 14

burning feet syndrome caused by which def

Answer 14

pantothenic acid b5

Question 15

which synthetic steroid requires bioactivation

Answer 15

prednison

Question 16

chemotherapy regimen for hodgkins

Answer 16

Adriamycine (doxorubicin)
Bleomycine
vinblastine
Dacarbazine

Question 17

residents of a nursing hoime that have rhinorrhea, non productive cough, headaches, myalgias normally have what disease

Answer 17

influenza

Question 18

late protein synthesis inhbitors

Answer 18

amprenavir

Question 19

viral adsorption inhib

Answer 19

gamma globulins … increase hep A immunity

Question 20

diffusion of oxygen into alveolar walls decreases in what condition

Answer 20

emphysema due to smoking , emphysema damages the alveolar walls

Question 21

decreased ability of hb to bind oxygen

Answer 21

sickle cell anemia of CO poisoning

Question 22

multiple nodular opacities that appear scattered throughout the peripheral lmph nodes and upper lobe

Answer 22

silicosis

exposure to rock mineral sand and smoking

Question 23

mucous gland hypertrophy and hyperplasisa seen in

Answer 23

bronchitis

Question 24

irregular non septate hyphae branching at 100 deg

Answer 24

mucor

Question 25

BRAF oncogene mutation

Answer 25

papillary thyroid carcinoma

Question 26

RAS

Answer 26

follicular thyroid carcinoma

Question 27

what pattern of lung disease is obesity assoc with

Answer 27

restrictive pattern due to the increased inward recoil of chest wall

Question 28

kidney transplant pt .. fever cough and acid fast stain shows long branching filaments

Answer 28

nocardia … txt with sulfonamides

Question 29

new bord with ARDS what do u do

Answer 29

treat with exogenous phosphatidylcholine although it does NOT reverse the pathology

Question 30

a child from congo … history of fever ,,, no vaccination ,,, right hip is externally rotated …inc WBC count….. aspiration of joint shows organism that grows on choclte agar not blood agar …. wht is the virulence factor of this organism

Answer 30

a capsule
H. influenza
signs of septic arthritis

Question 31

which cephalosporin has activity against pseudomonas

Answer 31

ceftazidime

Question 32

child irritable watery diarrhea and fever …. N myc oncogene

Answer 32

neuroblastoma … adrenal glands

Question 33

mutations of c kit gene

Answer 33

gastro stromal tumors

Question 34

C myc mutations

Answer 34

Burkitt lymphoma t 8 14

Question 35

primary prevention

Answer 35

interventions to prevent onset of the disease

Question 36

secondary prevention

Answer 36

identifying the asymptomatic disease in pt and stopping its progression

Question 37

tertiary prev

Answer 37

diagnosing the disease and treating it to reduce morbidity

Question 38

what is the function of surfactant

Answer 38

decrease alveolar surface tension and increase compliance

Question 39

mechanism cross link DNA and causes peripheral neuropathy

Answer 39

cisplatin

Question 40

increase number of mucous plugs and smooth muscle cell prolif

Answer 40

in ashma patients

Question 41

desquamation of resp epithelium

Answer 41

bronciectasis

Question 42

a drug that breaks DNA strands through free radical formation

Answer 42

bleomycin and causes p fibrosis

Question 43

pt presents with classic symp of influenza and gets treated with oseltamivir … starts feeling better but now has fever and coughing up green sputum… xray confirms lower lobe consolidation

Answer 43

this is bacterial pneumo after influenza inf

can be strept pyogenes (M protein), staph aureus, h influenza (capsule), strept pneumo (igA protease)