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2024 - élo - usmle rx qbank > resp onc 10 11 > Flashcards

resp onc 10 11 Flashcards

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USMLE® Step 1 flashcards
1
Q

flavivirus

A

hep c

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2
Q

hepadena virus

A

hep b

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3
Q

Chinese patients has liver mass … liver enzymes increased and complains of abd pain

A

hep b virus

C is usually asymptomatic and some sort of history with blood mixing shd be present (drugs tatoos etc)

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4
Q

lisch nodules

A

NF 1 ch 17

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5
Q

pt with shwanomas what else can u expect

A

NF2 ch 22 merlin gene

meningiomas, eye tumors and cataracts

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6
Q

loss of parasympathetic fibers carried by CN III would cause

A

mydriasis

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7
Q

atypical pneumonia what is the most sensitive method to identify the causative organism

A

mycoplasma

nasopharyngeal PCR

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8
Q

long term treatment for asthma

A

B2 agonist long acting

Gs stimulation

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9
Q

inhibition of protein kinase A

A

bbblockers

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10
Q

mass in left frontal lobe … fried egg appearance

A

oligodendroglioma

oligocytes sued to myelinate central axons

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11
Q

pt has burning senstation in mouth …. intermittent asthma … whitish film on tongue and inside cheeks … persistent day time cough and nighttime awakening
diag and txt

A

nystatin

candida infection …. pts with asthma can be txt with steroids that increases risk of candida infection

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12
Q

Ascaris, hookworms, and pinworms.

A

albendazole

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13
Q

terabinafine mechanism

A

inhibits squalene oxidase

txt for onnychomycosis

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14
Q

whch medication decreases synthesis of estrogen and progesterone

A

leuprolide

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15
Q

flutamide

A

antiandrogen …. blocks the androgen receptors

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16
Q

abundant RER can be seen in which disease

A

Multiple myeloma … malignant prolif of plasma cells … plasma cells are differentiated B cells that can releas specific antibodies

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17
Q

peroxisomes

A

fatty acid metabolism

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18
Q

MM what can be seen interms of kidney

A

proteinuria

bence jones

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19
Q

female itchy ulcerated lesion of the nipple

what underlying condition to check for

A

pagets disease
large halo like cells on histo
check for in situ or invasive ductal carcinoma

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20
Q

can phyllodes tumors cause ulceration

A

yes but not eczematous rsahs

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21
Q

hodkin lymphoma txt

A 
ABVD
adramycin
bleomycin
vinblastine
dacarbazine
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22
Q

cyclosproin

A

rmmber it is an immunesuppp

so use in autoimmune diseasea

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23
Q

pt has CML … after txt he presents with crackles in lungs cough and dyspnea … what drug is causing these symp

A

busulfan … alkylating agent

imatinib is more linked with joint pain, edema, vomiting etc

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24
Q

uterus larger than expected … BHG higher than expected… what is diag and complication

A

hydatiform mole ./…. choriocarcinoma

25
Q

30 years old female …. knee pain… tender effusion and xray reveals distal epiphyseal lesion ,,,, nonsclerotic and sharply defined border

A

giant cell tumor

age 20-40 more common in women

26
Q

younger boys and onion skin on xray … diaphysis of bone

A

ewings sarcoma t 11 22

27
Q

tumor has bimodal age distribution …. grows on metaphysis of bone … codmans triangle periosteal shadow or sunburst appearanceq

A

osteosarcoma,a

28
Q

which cells are the main responders in chronic bronvhitis

A

CD8 toxic t cells

29
Q

Infiltration of eosinophils and CD4+ lymphocytes is characteristically seen

A

asthma

30
Q

Necrotizing vasculitis and granulomatous eosinophilic tissue infiltration is characteristic of

A

eosinophilic granulomatosis churg strauss

31
Q

appearance of a “pearly papule” with telangiectasias

A

BCC

32
Q

Ziehl-Neelsen s

A

mycoplsma

33
Q

n both CLL and SLL, the body produces high numbers of abnormal B-lymphocytes.

A

function in humoral immunity

34
Q

pt in locked in state …. on ventilatot … daughter expresses her father didn’t want to be kept alive on machines
as a physician what do u do

A

respect autonomy

take offff ventilator

35
Q

what other signs can be seen with tension pneumothorax

A

JVD due to increased intrathoracic pressure

36
Q

Pancoast tumors noemally strangulate

A

second order preganglioninc sympathetic neuron that pass thru inferior cervical or stellate ganglion

37
Q

first order sympathetic damage would occur in

A

lesion at level of cervical spinal cord, hypothalamus upper thoracic spinal cord

38
Q

third order sympathetic involvement

A

injuries superior to thoracic cavty such as carotid dissection

39
Q

retinoblastoma in a patient explain the mutation (I chose inherited)

A

rmmber Tumor suppressor genes require a two hit hypoth

so the first Rb was mutated but in order to get the cancer SPORADIC mutation of the other gene must take place

40
Q

clearance of drug formula

A

0.7 x Vd /t1/2

41
Q

tumor lysis syndrome lab findings

A

hypocalcemia with hyperphosphatemia, hyperkalemia, hyperuricemia
txt allopurinol

42
Q

ER +ve breast cancer in postmenopausal women .. after resection what drug do u place her on

A

aromatiase inhib

testost-estradiol

43
Q

Hodgkin disease txt

A

BEACOPP cancer chemotherapy regimen: Bleomycin, Etoposide, doxorubicin (Adriamycin), Cyclophosphamide, vincristine (Oncovin), Procarbazine, and Prednisone.

44
Q

C3b function

A

potent opsonin

45
Q

IL3 function

A

like GM CSF prolif of myeloid lioneage

46
Q

mediators of anaphylaxis

A

C3a C5a

47
Q

abnormal prolif of metanephric blastema

A

Wilms tumor

48
Q

malignant transformation of renal tubular cells

A

RCC

49
Q

which electrolyte imbalance is closely related to disorientation and coma

A

hyponatremia

50
Q

t 14 18 translocation

A

follicular B cell …. BCL2 on ch 18 is antiapoptotic

51
Q

t 11 14

A

mantle cell lymphoma …. cyclin 1 in an oncogne

52
Q

c myc activation

A

Burkitt … oncognene

53
Q

what is defective in ataxia telengectasia

A

DNA repair mechanism

54
Q

Noninflamed (or “cold”) skin abscesses , coarse facies and retained primary teeth

A

job syndrome … hyper igE

55
Q

ttp eczem recurrent infc

A

wiskot Aldrich

56
Q

cystic enlargement of the liver, berry aneurysms, hypertension, and mitral valve prolapse.

A

APKD

57
Q

childhood supratentorial tumor and presents with headaches and bitemporal hemianopia

A

craniopharyngioma

58
Q

Waldenstrom macroglobulinemia typically presents with hyperviscosity syndrome, adenopathy, and hepatosplenomegaly

A

also IgM

59
Q

BCR-ABL is a 9;22 chromosomal fusion resulting in constitutively active tyrosine kinase.

A

this is an activation of proto oncogene

2024 - élo - usmle rx qbank (29 decks)

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