Resistance Mutations

Question 1

Resistance mutation in HEV which may lead to ribavirin resistance

Answer 1

G1634R in HEV pol

Question 2

Most common resistance mutations for lamivudine resistance in HBV

Answer 2

M204I/V

+/- L180M

Question 3

Pritelivir resistance mutation in HSV-1

Answer 3

A899T - in UL52

Question 4

What do the following HIV mutations confer resistance to?

K65R
M184V
L74V

Answer 4

Tenofovir (and most other NRTIs)

Lamivudine and emtricitibine (increases susceptibility to tenofovir)

Abacavir

Question 5

What does Q151M mutation cause?

Answer 5

Resistance to all NRTIs

Question 6

What do K103N mutation cause?

Answer 6

NNRTI resistance

Question 7

What does mutation Q148K in HIV cause?

Answer 7

Integrase resistance

Question 8

Name two HIV integrase mutations

Answer 8

G118R

Q148H/R/K

N155H

Question 9

Name two multi-drug NRTI mutations

Answer 9

T69ins

Q151M

Question 10

Resistance mutations to lenacapavir in HIV

Answer 10

Many in vitro but not many in vivo, below two have been found in patients:

M66I

Q67H/K/N/Y

K70H/N

N74D