HPV

Question 1

What type of virus is HPV?

Answer 1

dsDNA non-enveloped

Question 2

Which are the highest risk HPV types?

Answer 2

Type 16 (60%) and Type 18 (15%) and 11 more types

Question 3

Which HPV types cause genital warts?

Answer 3

Type 6 and 11 cause 90%

Question 4

How is cervical cancer screening performed?

Answer 4

Since 2019 screening changed from cytology to HPV screening
If HPV detected > cytology > colposcopy

Question 5

Which two platforms are validated for NHS HPV screening?

Answer 5

Hologic ‘Aptima HPV Assay’ on Panther

BD ‘Onclarity HPV Assay’

Both detect 14 high risk HPV types

Question 6

What type of vaccine is the HPV vaccine?

How is it produced?

What HPV types are in the vaccine?

What is the efficacy of the vaccine?

Answer 6

Subunit virus like particles

Grown in yeast or baculovirus infected cells

Gardasil 9 - 6, 11, 16, 18, 31, 33, 45, 52, 58

99% effective at reducing cancers caused by types in vaccine and genital warts

Question 7

What age is HPV vaccine licensed from?

What is the UK schedule?

Answer 7

Licensed from aged 9

From age 11-25 years - one dose
From 25 y+ = 2 doses 6-24 m apart
HIV/immunosuppressed = 3 doses 0, 1, 4 months