Dosages

Question 1

Dose of tecovirimat for hospitalised mpox

Answer 1

600 mg TDS for 14 days

Question 2

VZV pneumonitis treatment

Answer 2

10 mg/kg IV aciclovir TDS for 5-10 days

Question 3

Treatment for neonatal varicella

Answer 3

20 mg/kg IV aciclovir TDS for at least 7 days

Question 4

Treatment of pregnant women with chickenpox

Answer 4

Aciclovir 800 mg 5 times a day or valaciclovir 1000 mg TDS, for 7 days from onset of rash

Question 5

Dose of cidofovir?

Answer 5

IV 5 mg/kg weekly for 2 weeks then every 1-2 weeks.

OR

1 mg/kg 3 times a week

Always give with oral probenecid and IV sodium chloride 0.9% to prevent nephrotoxicity

Question 6

Dosage of aciclovir for genital herpes.

1. Primary infection
2. Recurrent infection
3. Severe infection
4. Suppressive therapy
5. Suppressive dose in pregnancy

Answer 6

1. 400 mg TDS 5 days
2. 800 mg TDS 2 days
3. IV 5 mg/kg TDS 5 days
4. 400 mg BD
5. 400 mg TDS from 32 weeks (or BD from 22-32 weeks if high risk of premature delivery)

Question 7

Treatment for neonatal HSV

Answer 7

IV aciclovir 20 mg/kg TDS for 14 days if SEM (skin, eye, mouth) 21 days for CNS or disseminated

Question 8

Dose of valaciclovir for prevention of cCMV in primary infection in periconception/first trimester

Answer 8

8g per day asap until amniocentesis

Question 9

Treatment and dosage for CMV prophylaxis

Answer 9

Ganciclovir 5 mg/kg OD
Valganciclovir 900 mg OD

Question 10

First line treatment of CMV disease

Answer 10

IV ganciclovir 5 mg/kg BD for 14-21 days

OR

Valganciclovir 900 mg BD (this is as effective as IV)

Question 11

Treatment for CMV pre-emptive prophylaxis

Answer 11

Ganciclovir 5 mg/kg BD (treatment dose) for 7-14 days then switch to 5 mg/kg OD (prophylaxis dose)

Question 12

Dose of foscarnet for CMV treatment

Answer 12

60 mg/kg TDS for 2-3 weeks

Question 13

Dose of foscarnet for HSV treatment

Answer 13

40 mg/kg TDS for 2-3 weeks

Question 14

Treatment of avian influenza

Answer 14

75 mg BD oseltamivir for 5 days

Question 15

Dose of val/aciclovir for post exposure prophylaxis for varicella?

1 - children under 2
2 - children 2-17
3 - adults

Answer 15

1 - 10 mg/kg QDS (d7-14 post exposure)*
Valaciclovir not recommended

2 - 10 mg/kg (up to 800 mg) QDS or valaciclovir 20 mg/kg (up to 1000 mg) TDS (d7-14 post exposure)

3. 800 mg QDS or 1000mg TDS (d7-14 post exposure)

*excluding those whose mothers develop chickenpox 7 days before to 7 days after birth

Question 16

Treatment of uncomplicated chickenpox?

Treatment of shingles?

Answer 16

800 mg 5 times a day for 7 days - if presenting within 24 h of rash onset

800 mg 5 times a day for 7 days - if presenting within 72 h of rash onset (or up to one week if high risk)

Question 17

Dose of ribavirin for chronic HEV

Answer 17

600 mg/day (optimum dose unknown)

Question 18

Dose of ribavirin for chronic HEV

Answer 18

600 mg/day (optimum dose unknown)

Question 19

If renal function of an elderly patient is not known in an influenza outbreak situation what dose of oseltamivir should be used?

Answer 19

30 mg BD for 5 days

(Dose for CrCl 31-60 ml/min)

Question 20

Dose of IVIG in ‘high dose’ IVIG use

Answer 20

1-4 g/kg

Question 21

Dose of pritelivir?

Answer 21

100 mg OD (used in genital herpes)

Benefits are single daily doses as longer half life than aciclovir