Dosages Flashcards

1
Q

Dose of tecovirimat for hospitalised mpox

A

600 mg TDS for 14 days

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2
Q

VZV pneumonitis treatment

A

10 mg/kg IV aciclovir TDS for 5-10 days

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3
Q

Treatment for neonatal varicella

A

20 mg/kg IV aciclovir TDS for at least 7 days

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4
Q

Treatment of pregnant women with chickenpox

A

Aciclovir 800 mg 5 times a day or valaciclovir 1000 mg TDS, for 7 days from onset of rash

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5
Q

Dose of cidofovir?

A

IV 5 mg/kg weekly for 2 weeks then every 1-2 weeks.

OR

1 mg/kg 3 times a week

Always give with oral probenecid and IV sodium chloride 0.9% to prevent nephrotoxicity

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6
Q

Dosage of aciclovir for genital herpes.

  1. Primary infection
  2. Recurrent infection
  3. Severe infection
  4. Suppressive therapy
  5. Suppressive dose in pregnancy
A
  1. 400 mg TDS 5 days
  2. 800 mg TDS 2 days
  3. IV 5 mg/kg TDS 5 days
  4. 400 mg BD
  5. 400 mg TDS from 32 weeks (or BD from 22-32 weeks if high risk of premature delivery)
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7
Q

Treatment for neonatal HSV

A

IV aciclovir 20 mg/kg TDS for 14 days if SEM (skin, eye, mouth) 21 days for CNS or disseminated

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8
Q

Dose of valaciclovir for prevention of cCMV in primary infection in periconception/first trimester

A

8g per day asap until amniocentesis

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9
Q

Treatment and dosage for CMV prophylaxis

A

Ganciclovir 5 mg/kg OD
Valganciclovir 900 mg OD

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10
Q

First line treatment of CMV disease

A

IV ganciclovir 5 mg/kg BD for 14-21 days

OR

Valganciclovir 900 mg BD (this is as effective as IV)

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11
Q

Treatment for CMV pre-emptive prophylaxis

A

Ganciclovir 5 mg/kg BD (treatment dose) for 7-14 days then switch to 5 mg/kg OD (prophylaxis dose)

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12
Q

Dose of foscarnet for CMV treatment

A

60 mg/kg TDS for 2-3 weeks

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13
Q

Dose of foscarnet for HSV treatment

A

40 mg/kg TDS for 2-3 weeks

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14
Q

Treatment of avian influenza

A

75 mg BD oseltamivir for 5 days

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15
Q

Dose of val/aciclovir for post exposure prophylaxis for varicella?

1 - children under 2
2 - children 2-17
3 - adults

A

1 - 10 mg/kg QDS (d7-14 post exposure)*
Valaciclovir not recommended

2 - 10 mg/kg (up to 800 mg) QDS or valaciclovir 20 mg/kg (up to 1000 mg) TDS (d7-14 post exposure)

  1. 800 mg QDS or 1000mg TDS (d7-14 post exposure)

*excluding those whose mothers develop chickenpox 7 days before to 7 days after birth

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16
Q

Treatment of uncomplicated chickenpox?

Treatment of shingles?

A

800 mg 5 times a day for 7 days - if presenting within 24 h of rash onset

800 mg 5 times a day for 7 days - if presenting within 72 h of rash onset (or up to one week if high risk)

17
Q

Dose of ribavirin for chronic HEV

A

600 mg/day (optimum dose unknown)

18
Q

Dose of ribavirin for chronic HEV

A

600 mg/day (optimum dose unknown)

19
Q

If renal function of an elderly patient is not known in an influenza outbreak situation what dose of oseltamivir should be used?

A

30 mg BD for 5 days

(Dose for CrCl 31-60 ml/min)

20
Q

Dose of IVIG in ‘high dose’ IVIG use

21
Q

Dose of pritelivir?

A

100 mg OD (used in genital herpes)

Benefits are single daily doses as longer half life than aciclovir

22
Q

Dose and duration of dexamethasone for COVID patients.

Alternative in pregnancy?

A

6 mg per day for 10 days for those requiring oxygen

Prednisolone 40 mg per day for 10 days in pregnant women

23
Q

Dose and duration of oseltamivir for influenza treatment in severely immunosuppressed patient

A

75 mg BD for 10 days

24
Q

Dose and duration of Zanamavir treatment for influenza

A

10 mg inhaler BD for 5 days

25
Dose of aciclovir for encephalitis in >12 years and children (3 m to 12 y)
10 mg/kg every 8 hours 500 mg/m2 every 8 hours
26
What is the dose for Nirsevimab (Beyfortus)
<5 kg = 50 mg >5 kg = 100 mg
27
Dose of foscarnet for HHV-6 encephalitis
90 mg/kg BD for at least 3 weeks and until CSF and blood negative
28
Dose of ganciclovir for HHV-6 encephalitis
IV 5 mg/kg BD for at least 3 weeks and until blood and CSF negative
29
Dose of HBIG for 10+ years
500 IU
30
Dose of HBIG for neonate born to mother with HBV?
250 IU
31
Dose of ribavirin in HCV treatment
600 mg OD for 12 weeks alongside DAAs
32
What is the dose of letermovir for CMV prophylaxis in: a) HSCT b) HSCT when coadministered with cyclosporin
a) 480 mg once daily b) 240 mg once daily
33
Dose of tenofovir for HBV treatment
245 mg OD
34
Dose of entecavir for hep B
500 mg OD (or 1g if decompensated or lamivudine resistance)