Dosages Flashcards
Dose of tecovirimat for hospitalised mpox
600 mg TDS for 14 days
VZV pneumonitis treatment
10 mg/kg IV aciclovir TDS for 5-10 days
Treatment for neonatal varicella
20 mg/kg IV aciclovir TDS for at least 7 days
Treatment of pregnant women with chickenpox
Aciclovir 800 mg 5 times a day or valaciclovir 1000 mg TDS, for 7 days from onset of rash
Dose of cidofovir?
IV 5 mg/kg weekly for 2 weeks then every 1-2 weeks.
OR
1 mg/kg 3 times a week
Always give with oral probenecid and IV sodium chloride 0.9% to prevent nephrotoxicity
Dosage of aciclovir for genital herpes.
- Primary infection
- Recurrent infection
- Severe infection
- Suppressive therapy
- Suppressive dose in pregnancy
- 400 mg TDS 5 days
- 800 mg TDS 2 days
- IV 5 mg/kg TDS 5 days
- 400 mg BD
- 400 mg TDS from 32 weeks (or BD from 22-32 weeks if high risk of premature delivery)
Treatment for neonatal HSV
IV aciclovir 20 mg/kg TDS for 14 days if SEM (skin, eye, mouth) 21 days for CNS or disseminated
Dose of valaciclovir for prevention of cCMV in primary infection in periconception/first trimester
8g per day asap until amniocentesis
Treatment and dosage for CMV prophylaxis
Ganciclovir 5 mg/kg OD
Valganciclovir 900 mg OD
First line treatment of CMV disease
IV ganciclovir 5 mg/kg BD for 14-21 days
OR
Valganciclovir 900 mg BD (this is as effective as IV)
Treatment for CMV pre-emptive prophylaxis
Ganciclovir 5 mg/kg BD (treatment dose) for 7-14 days then switch to 5 mg/kg OD (prophylaxis dose)
Dose of foscarnet for CMV treatment
60 mg/kg TDS for 2-3 weeks
Dose of foscarnet for HSV treatment
40 mg/kg TDS for 2-3 weeks
Treatment of avian influenza
75 mg BD oseltamivir for 5 days
Dose of val/aciclovir for post exposure prophylaxis for varicella?
1 - children under 2
2 - children 2-17
3 - adults
1 - 10 mg/kg QDS (d7-14 post exposure)*
Valaciclovir not recommended
2 - 10 mg/kg (up to 800 mg) QDS or valaciclovir 20 mg/kg (up to 1000 mg) TDS (d7-14 post exposure)
- 800 mg QDS or 1000mg TDS (d7-14 post exposure)
*excluding those whose mothers develop chickenpox 7 days before to 7 days after birth
Treatment of uncomplicated chickenpox?
Treatment of shingles?
800 mg 5 times a day for 7 days - if presenting within 24 h of rash onset
800 mg 5 times a day for 7 days - if presenting within 72 h of rash onset (or up to one week if high risk)
Dose of ribavirin for chronic HEV
600 mg/day (optimum dose unknown)
Dose of ribavirin for chronic HEV
600 mg/day (optimum dose unknown)
If renal function of an elderly patient is not known in an influenza outbreak situation what dose of oseltamivir should be used?
30 mg BD for 5 days
(Dose for CrCl 31-60 ml/min)
Dose of IVIG in ‘high dose’ IVIG use
1-4 g/kg
Dose of pritelivir?
100 mg OD (used in genital herpes)
Benefits are single daily doses as longer half life than aciclovir
Dose and duration of dexamethasone for COVID patients.
Alternative in pregnancy?
6 mg per day for 10 days for those requiring oxygen
Prednisolone 40 mg per day for 10 days in pregnant women
Dose and duration of oseltamivir for influenza treatment in severely immunosuppressed patient
75 mg BD for 10 days
Dose and duration of Zanamavir treatment for influenza
10 mg inhaler BD for 5 days
Dose of aciclovir for encephalitis in >12 years and children (3 m to 12 y)
10 mg/kg every 8 hours
500 mg/m2 every 8 hours
What is the dose for Nirsevimab (Beyfortus)
<5 kg = 50 mg
> 5 kg = 100 mg
Dose of foscarnet for HHV-6 encephalitis
90 mg/kg BD for at least 3 weeks and until CSF and blood negative
Dose of ganciclovir for HHV-6 encephalitis
IV 5 mg/kg BD for at least 3 weeks and until blood and CSF negative
Dose of HBIG for 10+ years
500 IU
Dose of HBIG for neonate born to mother with HBV?
250 IU
Dose of ribavirin in HCV treatment
600 mg OD for 12 weeks alongside DAAs
What is the dose of letermovir for CMV prophylaxis in:
a) HSCT
b) HSCT when coadministered with cyclosporin
a) 480 mg once daily
b) 240 mg once daily
Dose of tenofovir for HBV treatment
245 mg OD
Dose of entecavir for hep B
500 mg OD (or 1g if decompensated or lamivudine resistance)
