resistance

Question 1

Gene Amplification

Answer 1

↑ in gene copy # & gene product (make 10x the product), renders clinical dosage ineffective

Question 2

Alteration in Protein Structure

Answer 2

change in gene structure w/o amplification 🡪 different protein characteristics; drug won’t work anymore

Question 3

Decreased Enzyme Activity

Answer 3

↓ gene expression of proteins required for drug metabolisms so active analogues aren’t synthesized (drug doesn’t get activated so useless)

Question 4

P-Glycoprotein Alteration

Answer 4

change in membrane transport properties; either the drug isn’t absorbed in the cell or ↑ removal

Question 5

DNA Repair

Answer 5

DNA repair pathways that protect healthy cells also protect cancer cells