Cell cycle specific

Question 1

Hydroxyurea

Answer 1

anti-metabolites that blocks thymidylate and DNA synthesis

Question 2

Doxorubicin

Answer 2

block topoisomerase II and intercalates DNA;

Question 3

Irinotecan

Answer 3

plant alkaloids that blocks topo I

Question 4

Paclitaxel

Answer 4

plant alkaloid that block microtubule formation;

Question 5

6-mercaptopurine

Answer 5

thiopurine antagonist that inhibits DNA syn

Question 6

5-fluorouracil

Answer 6

nti-metabolite that blocks thymidylate and DNA syn

Question 7

Methotrexate

Answer 7

dihydrofolate reductase (DHFR) inhibitor
Drug-drug interactions can occur with NSAIDS, penicillin, and cephalosporins as these drugs will inhibit MTX excretion

Question 8

Vincristine

Answer 8

blocks beta-tubulin and destabilizes it

Question 9

Palbociclib

Answer 9

inhibits CDK4/6 and the cell will be arrested in G1 w/ adverse effects like myelosuppression, headache, anemia, nausea, and diarrhea, orally bioavailable, substrate and inhibitor of CYP3A,
should avoid grapefruit juice and St. John’s Wort due to drug-drug interactions,

Question 10

Cytarabine

Answer 10

blocks thymidylate and DNA syn; lecture 5 slide 13: inhibits ribonucleotide reductase blocking the production of dNTPs

Question 11

leucovorin

Answer 11

antidote to MTX