mAb for cancers

Question 1

Trastuzumab

Answer 1

targets ErbB2 [HER2 (human epidermal growth factor receptor 2)] that is involved with mammary carcinoma; lecture 5 slide 37 MAB chart: targets HER2 by inhibiting cell growth,

Question 2

Bevacizumab

Answer 2

targets VEGF and is involved in lung cancer and colorectal cancer;

Question 3

Cetuximab

Answer 3

targets EGFR and targets colorectal cancer, head and neck cancer; l

Question 4

Ipilimumab

Answer 4

targets CTLA-4, MOA is inhibits immune cell tolerance to activate T-cell to recognize cancer cell, for metastatic melanoma and no drug combination