NSAIDs

Question 1

aspirin

Answer 1

irreversible inhibition of COX-1, inhibits platelet aggregation, induction of tumor suppressor genes, anagesic antipyretic, anti inflammatory(AAA)

GI intolerance, excessive bleeding, drowsiness, rash

Question 2

Ibuprofen

Answer 2

cox inhibition

GI, can interactw ith other high plasma binding drugs liek warfarin

Question 3

Fenoprofen

Answer 3

RA, mild to modeate pain, osteoarthritis

Question 4

acetaminophen

Answer 4

allows wound healing, weak cox inhibitor, analgesic

Can add to oxidative stress, depletes glutathione which disrupts detoxing in liver. NAC is a godo antidote.

Question 5

Ketoprofen

Answer 5

gum tooth pain and inflammation,

v

Question 6

Indomethacin

Answer 6

inhibits COX1 and COX2, AAA, godo for RA and gout and osteoporosis

GI intolerance, allergies under 2, renal liver damage, hypertension, parkinsons

Adjuvant for gout, not fo rmaintenance therapy.

Question 7

ketarolac

Answer 7

potent analgesic, opioid sparing drug

kidney damage past five days, renal bloodflow compromised long term use due to blocking prostaglandins